Digital selective transformation and patterning of highly conductive hydrogel bioelectronics by laser-induced phase separation.

ABSTRACT

The patterning of poly(3,4-ethylenedioxythiophene)poly(styrene sulfonate) (PEDOTPSS) hydrogels with excellent electrical property and spatial resolution is a challenge for bioelectronic applications. However, most PEDOTPSS hydrogels are fabricated by conventional manufacturing processes such as photolithography, inkjet printing, and screen printing with complex fabrication steps or low spatial resolution. Moreover, the additives used for fabricating PEDOTPSS hydrogels are mostly cytotoxic, thus requiring days of detoxification. Here, we developed a previously unexplored ultrafast and biocompatible digital patterning process for PEDOTPSS hydrogel via phase separation induced by a laser. We enhanced the electrical properties and aqueous stability of PEDOTPSS by selective laser scanning, which allowed the transformation of PEDOTPSS into water-stable hydrogels. PEDOTPSS hydrogels showed high electrical conductivity of 670 S/cm with 6-µm resolution in water. Furthermore, electrochemical properties were maintained even after 6 months in a physiological environment. We further demonstrated stable neural signal recording and stimulation with hydrogel electrodes fabricated by laser.