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Improvement of Work Productivity and Quality of Life with Anti-Tumor Necrosis Factor Treatment Used in Crohn's Disease in Routine Clinical Practice in Turkey.
Toruner, Murat; Basaranoglu, Metin; Atug, Ozlen; Senturk, Omer; Akyuz, Filiz; Cekic, Cem; Over Hamzaoglu, Hulya; Tekin, Fatih; Sezgin, Orhan; Akpinar, Hale; Celik, Aykut Ferhat; Tezel, Ahmet; Gokturk, Huseyin Savas; Kav, Taylan.
Affiliation
  • Toruner M; Department of Gastroenterology, Ankara University Faculty of Medicine, Ibn-i Sina Hospital, Ankara, Turkey.
  • Basaranoglu M; Department of Gastroenterology, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey.
  • Atug O; Department of Gastroenterology, Marmara University School of Medicine, Istanbul, Turkey.
  • Senturk O; Department of Gastroenterology, Kocaeli University Faculty of Medicine, Izmit, Turkey.
  • Akyuz F; Department of Gastroenterology, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.
  • Cekic C; Department of Gastroenterology, Izmir Katip Celebi University, Izmir, Turkey.
  • Over Hamzaoglu H; Department of Gastroenterology, Acibadem Fulya Hospital, Istanbul, Turkey.
  • Tekin F; Department of Gastroenterology, Ege University Medical School, Izmir, Turkey.
  • Sezgin O; Department of Gastroenterology, Mersin University Faculty of Medicine, Mersin, Turkey.
  • Akpinar H; Department of Gastroenterology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
  • Celik AF; Department of Gastroenterology, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey.
  • Tezel A; Department of Gastroenterology, Trakya University Faculty of Medicine, Edirne, Turkey.
  • Gokturk HS; Department of Gastroenterology, Baskent University Faculty of Medicine, Konya, Turkey.
  • Kav T; Department of Gastroenterology, Hacettepe University School of Medicine, Ankara, Turkey.
Turk J Gastroenterol ; 33(5): 406-413, 2022 05.
Article in En | MEDLINE | ID: mdl-35678798
BACKGROUND: Patients with Crohn's disease experience major deterioration in work productivity and quality of life. We aimed to provide the long-term effects of anti-tumor necrosis factor agents on work productivity and activity impairment and quality of life in patients with Crohn's disease using the Inflammatory Bowel Disease Questionnaire and the Short-Form Health Survey-36. METHODS: Patients with Crohn's disease and initiated an anti-tumor necrosis factor treatment were included and followed up for 12 months in this observational study. RESULTS: A total of 106 patients were included in this study, and 64.2% of the patients were males. Mean [± standard deviation] age was 36.8 [± 10.9] years. At baseline, mostly perianal fistulas [65.7%] were observed [n = 23]. Intestinal stenosis was detected in 34.9% of the patients [n = 37], and most of the stenosis was located in the ileum [70.6%] followed by the colon [20.6%]. Extraintestinal symp- toms were observed in 24 patients [22.6%]. Most frequent extraintestinal symptom was arthritis with 71.4% [n = 15]. Mean time from first symptom to initiation of anti-tumor necrosis factor treatment was 6.3 [± 5.0] years. Improvements in work productivity and activ- ity impairment scores throughout 12 months were -24.1% [P = .003] for work time missed, -18.0% [P = .006] for impairment at work, -8.5% [P = .160] for overall work impairment, and -17.0% [P < .001] for daily activity impairment. Similarly, significant improvements [P < .001] were detected in all components of the Inflammatory Bowel Disease Questionnaire when compared to baseline. Statistically sig- nificant improvements [P < .05] were detected for all components of Short-Form Health Survey-36 except for mental health [P = .095]. CONCLUSION: Our study indicates the significant improvement in work productivity and activity impairment and quality of life of patients with Crohn's disease who receive long-term anti-tumor necrosis factor treatment.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease Type of study: Observational_studies Aspects: Patient_preference Limits: Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Turk J Gastroenterol Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease Type of study: Observational_studies Aspects: Patient_preference Limits: Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Turk J Gastroenterol Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication: