Generation and characterisation of four multiple sclerosis iPSC lines from a single family.
Stem Cell Res
; 62: 102828, 2022 07.
Article
in En
| MEDLINE
| ID: mdl-35679759
ABSTRACT
Multiple sclerosis (MS) is a complex neuroinflammatory/degenerative disease of the central nervous system (CNS) that results in the formation of demyelinated lesions and axon degeneration. MS aetiology is complex, with genetics estimated to account for â¼48% of MS risk (International Multiple Sclerosis Genetics Consortium, 2019). Despite this, families with a high incidence of MS are rare. We have generated four induced pluripotent stem cell (iPSC) lines from individuals with relapsing-remitting and secondary progressive MS within a single family. The generation of disease-specific iPSC lines from multiple members of a single family will facilitate MS genetic and functional studies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Induced Pluripotent Stem Cells
/
Multiple Sclerosis
Limits:
Humans
Language:
En
Journal:
Stem Cell Res
Year:
2022
Document type:
Article
Affiliation country: