Maternal Testosterone and Offspring Birth Weight: A Mendelian Randomization Study.
J Clin Endocrinol Metab
; 107(9): 2530-2538, 2022 08 18.
Article
in En
| MEDLINE
| ID: mdl-35758857
ABSTRACT
CONTEXT Evidence has shown maternal androgen levels in both the general population and populations with hyperandrogenic disorders are inversely associated with offspring birth weight. CONTEXT We aimed to investigate the causal effect of maternal testosterone levels in the general population on offspring birth weight and preterm delivery risk using a two-sample Mendelian randomization (MR) method. METHODS:
We obtained independent genetic instruments from a sex-specific genome-wide association study with up to 230 454 females of European descent from the UK Biobank. Genetic instruments with consistent testosterone effects but no aggregate effect on sex hormone-binding globulin were used to perform the main analysis. Summary-level data of offspring birth weight adjusted for genotype were obtained from a study with 210 406 females of European descent. Summary-level data of preterm delivery were obtained from the FinnGen study (6736 cases and 116 219 controls).RESULTS:
MR analysis showed that each SD (0.62 nmol/L) increase in testosterone levels could reduce the offspring birth weight by 37.26 g (95% CI,â 19.59-54.94 g; Pâ =â 3.62â ×â 10-5). Each SD increase in testosterone levels was also associated with an increased risk of preterm delivery (odds ratioâ =â 1.329; 95% CI, 1.161-1.520; Pâ =â 3.57â ×â 10-5). Similar results were found using different MR methods and multivariable MR analyses.CONCLUSION:
This two-sample MR study showed genetically determined higher circulating testosterone levels in females from the general population were associated with low birth weight of offspring and increased risk of preterm delivery.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Premature Birth
/
Mendelian Randomization Analysis
Type of study:
Clinical_trials
Limits:
Female
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Humans
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Male
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Newborn
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
2022
Document type:
Article
Affiliation country: