[Mechanism of human airway epithelial cell injury induced by Candida albicans infection].
Zhonghua Yi Xue Za Zhi
; 102(25): 1924-1930, 2022 Jul 05.
Article
in Zh
| MEDLINE
| ID: mdl-35768392
Objective: To investigate the immune mechanism of human airway epithelial cell injury induced by invasion of Candida albicans with different biofilm formation abilities. Methods: Twenty-five strains of Candida albicans isolated and cultured in General Hospital of Ningxia Medical University from June to December 2019 were selected, and quality control strain SC5314 was used as the standard strain. An in vitro model of Candida albicans biofilm was established, and the biofilm formation ability of different Candida albicans was detected by crystal violet staining and enzyme plate method. The absorbance value at 570 nm (A570) was determined by enzyme plate method. A570≥0.5, 0.250.05). Conclusion: Strong biofilm Candida albican can inhibit cell proliferation, disrupt the integrity of epithelial cells and induce cell damage by down-regulating the expression of cell proliferation-related protein.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Candida albicans
/
Candidiasis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Yi Xue Za Zhi
Year:
2022
Document type:
Article
Affiliation country:
Country of publication: