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miRNAs in Serum Exosomes for Differential Diagnosis of Brain Metastases.
Catelan, Silvia; Olioso, Debora; Santangelo, Alessandra; Scapoli, Chiara; Tamanini, Anna; Pinna, Giampietro; Sala, Francesco; Lippi, Giuseppe; Nicolato, Antonio; Cabrini, Giulio; Dechecchi, Maria Cristina.
Affiliation
  • Catelan S; Section of Neurosurgery, Department of Neurosciences, Biomedicines and Movement, University of Verona, 37126 Verona, Italy.
  • Olioso D; Section of Clinical Biochemistry, Department of Neurosciences, Biomedicines and Movement, University of Verona, 37126 Verona, Italy.
  • Santangelo A; Section of Clinical Biochemistry, Department of Neurosciences, Biomedicines and Movement, University of Verona, 37126 Verona, Italy.
  • Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, 40121 Ferrara, Italy.
  • Tamanini A; Section of Molecular Pathology, Department of Pathology and Diagnostics, University Hospital of Verona, 371234 Verona, Italy.
  • Pinna G; Institute of Neurosurgery A, Department of Neurosciences, University Hospital of Verona, 371234 Verona, Italy.
  • Sala F; Section of Neurosurgery, Department of Neurosciences, Biomedicines and Movement, University of Verona, 37126 Verona, Italy.
  • Lippi G; Institute of Neurosurgery B, Department of Neurosciences, University Hospital of Verona, 371234 Verona, Italy.
  • Nicolato A; Section of Clinical Biochemistry, Department of Neurosciences, Biomedicines and Movement, University of Verona, 37126 Verona, Italy.
  • Cabrini G; Section of Molecular Pathology, Department of Pathology and Diagnostics, University Hospital of Verona, 371234 Verona, Italy.
  • Dechecchi MC; Section of Stereotaxy, Department of Neurosciences, University Hospital of Verona, 371234 Verona, Italy.
Cancers (Basel) ; 14(14)2022 Jul 18.
Article in En | MEDLINE | ID: mdl-35884554
Circulating miRNAs are increasingly studied and proposed as tumor markers with the aim of investigating their role in monitoring the response to therapy as well as the natural evolution of primary or secondary brain tumors. This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR-124-3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs. A total of 105 patients with BMs from primary lung or breast cancer, or melanoma underwent neurosurgery or radiosurgery treatment, and 91 patients with HGGs were enrolled, along with 30 healthy controls. A significant increase in miR-21 expression in serum exosomes was observed in both HGGs and BMs compared with healthy controls; on the other hand, miR-124-3p was significantly decreased in BMs, and it was increased in HGGs. After the surgical or radiosurgical treatment of patients with BMs, a significant reduction in miR-21 was noted with both types of treatments. This study identified a signature of exosomal miRNAs that could be useful as a noninvasive complementary analysis both in the differential diagnosis of BMs from glial tumors and in providing information on tumor evolution over time.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: Cancers (Basel) Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: Cancers (Basel) Year: 2022 Document type: Article Affiliation country: Country of publication: