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Mechanistic Modeling of In Vitro Skin Permeation and Extrapolation to In Vivo for Topically Applied Metronidazole Drug Products Using a Physiologically Based Pharmacokinetic Model.
Arora, Sumit; Clarke, James; Tsakalozou, Eleftheria; Ghosh, Priyanka; Alam, Khondoker; Grice, Jeffery E; Roberts, Michael S; Jamei, Masoud; Polak, Sebastian.
Affiliation
  • Arora S; Certara UK Ltd, Simcyp Division, Sheffield S1 2BJ, U.K.
  • Clarke J; Certara UK Ltd, Simcyp Division, Sheffield S1 2BJ, U.K.
  • Tsakalozou E; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993, United States.
  • Ghosh P; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993, United States.
  • Alam K; Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993, United States.
  • Grice JE; Therapeutics Research Centre, Diamantina Institute, University of Queensland, Brisbane 4102, Australia.
  • Roberts MS; Therapeutics Research Centre, Diamantina Institute, University of Queensland, Brisbane 4102, Australia.
  • Jamei M; Clinical and Health Sciences, University of South Australia, Adelaide 5005, Australia.
  • Polak S; Certara UK Ltd, Simcyp Division, Sheffield S1 2BJ, U.K.
Mol Pharm ; 19(9): 3139-3152, 2022 09 05.
Article in En | MEDLINE | ID: mdl-35969125
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Metronidazole Type of study: Prognostic_studies Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Metronidazole Type of study: Prognostic_studies Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication: