Analytical Solution to the Flory-Huggins Model.
J Phys Chem Lett
; 13(33): 7853-7860, 2022 Aug 25.
Article
in En
| MEDLINE
| ID: mdl-35977086
ABSTRACT
A self-consistent analytical solution for binodal concentrations of the two-component Flory-Huggins phase separation model is derived. We show that this form extends the validity of the Ginzburg-Landau expansion away from the critical point to cover the whole phase space. Furthermore, this analytical solution reveals an exponential scaling law of the dilute phase binodal concentration as a function of the interaction strength and chain length. We demonstrate explicitly the power of this approach by fitting experimental protein liquid-liquid phase separation boundaries to determine the effective chain length and solute-solvent interaction energies. Moreover, we demonstrate that this strategy allows us to resolve differences in interaction energy contributions of individual amino acids. This analytical framework can serve as a new way to decode the protein sequence grammar for liquid-liquid phase separation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteins
Language:
En
Journal:
J Phys Chem Lett
Year:
2022
Document type:
Article
Affiliation country: