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An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections.
Parker, Erica N; Cain, Brett N; Hajian, Behnoush; Ulrich, Rebecca J; Geddes, Emily J; Barkho, Sulyman; Lee, Hyang Yeon; Williams, John D; Raynor, Malik; Caridha, Diana; Zaino, Angela; Shekhar, Mrinal; Muñoz, Kristen A; Rzasa, Kara M; Temple, Emily R; Hunt, Diana; Jin, Xiannu; Vuong, Chau; Pannone, Kristina; Kelly, Aya M; Mulligan, Michael P; Lee, Katie K; Lau, Gee W; Hung, Deborah T; Hergenrother, Paul J.
Affiliation
  • Parker EN; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Cain BN; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Hajian B; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
  • Ulrich RJ; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Geddes EJ; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Barkho S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
  • Lee HY; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Williams JD; Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 United States.
  • Raynor M; Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 United States.
  • Caridha D; Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 United States.
  • Zaino A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
  • Shekhar M; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
  • Muñoz KA; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Rzasa KM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
  • Temple ER; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
  • Hunt D; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
  • Jin X; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts 02115, United States.
  • Vuong C; Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 United States.
  • Pannone K; Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 United States.
  • Kelly AM; Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 United States.
  • Mulligan MP; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Lee KK; Department of Chemistry and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Lau GW; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
  • Hung DT; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • Hergenrother PJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
ACS Cent Sci ; 8(8): 1145-1158, 2022 Aug 24.
Article in En | MEDLINE | ID: mdl-36032774
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Cent Sci Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Cent Sci Year: 2022 Document type: Article Affiliation country: Country of publication: