CRISPR/Cas9 in the era of nanomedicine and synthetic biology.
Drug Discov Today
; 28(1): 103375, 2023 01.
Article
in En
| MEDLINE
| ID: mdl-36174966
ABSTRACT
The CRISPR/Cas system was first discovered as a defense mechanism in bacteria and is now used as a tool for precise gene-editing applications. Rapidly evolving, it is increasingly applied in therapeutics. However, concerns about safety, specificity, and delivery still limit its potential. In this context, we introduce the concept of nanogenetics and speculate how the rational engineering of the CRISPR/Cas machinery could advance the biomedical field. In nanogenetics, the advantages of traditional approaches of synthetic biology could be expanded by nanotechnology approaches, enabling the design of a new generation of intrinsically safe and specific genome-editing platforms.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nanomedicine
/
CRISPR-Cas Systems
Language:
En
Journal:
Drug Discov Today
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2023
Document type:
Article
Affiliation country: