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A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy.
Aoyagi, Kyota; Yamashita, Shun-Ichi; Akimoto, Yoshihiro; Nishiwaki, Chiyono; Nakamichi, Yoko; Udagawa, Haruhide; Abe, Manabu; Sakimura, Kenji; Kanki, Tomotake; Ohara-Imaizumi, Mica.
Affiliation
  • Aoyagi K; Department of Cellular Biochemistry, Kyorin University School of Medicine, Tokyo, Japan.
  • Yamashita SI; Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
  • Akimoto Y; Department of Microscopic Anatomy, Kyorin University School of Medicine, Tokyo, Japan.
  • Nishiwaki C; Department of Cellular Biochemistry, Kyorin University School of Medicine, Tokyo, Japan.
  • Nakamichi Y; Department of Cellular Biochemistry, Kyorin University School of Medicine, Tokyo, Japan.
  • Udagawa H; Department of Cellular Biochemistry, Kyorin University School of Medicine, Tokyo, Japan.
  • Abe M; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan.
  • Sakimura K; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan.
  • Kanki T; Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
  • Ohara-Imaizumi M; Department of Cellular Biochemistry, Kyorin University School of Medicine, Tokyo, Japan. mimaizu@ks.kyorin-u.ac.jp.
Diabetologia ; 66(1): 147-162, 2023 01.
Article in En | MEDLINE | ID: mdl-36181536
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Mitochondria Limits: Animals Language: En Journal: Diabetologia Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Mitochondria Limits: Animals Language: En Journal: Diabetologia Year: 2023 Document type: Article Affiliation country: Country of publication: