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Physical activity intensity is associated with cognition and functional connectivity in Parkinson's disease.
Donahue, Erin K; Venkadesh, Siva; Bui, Vy; Tuazon, Angelie Cabrera; Wang, Ryan K; Haase, Danielle; Foreman, Ryan P; Duran, Jared J; Petkus, Andrew; Wing, David; Higgins, Michael; Holschneider, Daniel P; Bayram, Ece; Litvan, Irene; Jakowec, Michael W; Van Horn, John Darrell; Schiehser, Dawn M; Petzinger, Giselle M.
Affiliation
  • Donahue EK; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, 90089, USA.
  • Venkadesh S; Department of Psychology, University of Virginia, Charlottesville, VA, 22904, USA.
  • Bui V; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
  • Tuazon AC; Veterans Administration San Diego Healthcare System (VASDHS), San Diego, CA, 92161, USA; Department of Psychiatry, University of California, San Diego, CA, 92093, USA.
  • Wang RK; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
  • Haase D; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
  • Foreman RP; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
  • Duran JJ; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
  • Petkus A; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
  • Wing D; Veterans Administration San Diego Healthcare System (VASDHS), San Diego, CA, 92161, USA; Herbert Wertheim School of Public Health, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0811, USA.
  • Higgins M; Veterans Administration San Diego Healthcare System (VASDHS), San Diego, CA, 92161, USA; Herbert Wertheim School of Public Health, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0811, USA.
  • Holschneider DP; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, 90089, USA; Department of Psychiatry & the Behavioral Sciences, University of Southern California, Los Angeles, CA, 90089, USA.
  • Bayram E; Parkinson and Other Movement Disorder Center, Department of Neurosciences, University of California San Diego, California, 92092-0886, USA.
  • Litvan I; Parkinson and Other Movement Disorder Center, Department of Neurosciences, University of California San Diego, California, 92092-0886, USA.
  • Jakowec MW; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.
  • Van Horn JD; Department of Psychology, University of Virginia, Charlottesville, VA, 22904, USA; School of Data Science, University of Virginia, Charlottesville, VA, 22904, USA.
  • Schiehser DM; Veterans Administration San Diego Healthcare System (VASDHS), San Diego, CA, 92161, USA; Department of Psychiatry, University of California, San Diego, CA, 92093, USA.
  • Petzinger GM; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA. Electronic address: petzinge@med.usc.edu.
Parkinsonism Relat Disord ; 104: 7-14, 2022 11.
Article in En | MEDLINE | ID: mdl-36191358
ABSTRACT

BACKGROUND:

Cognitive impairment is common in Parkinson's disease (PD) and often leads to dementia, with no effective treatment. Aging studies suggest that physical activity (PA) intensity has a positive impact on cognition and enhanced functional connectivity may underlie these benefits. However, less is known in PD. This cross-sectional study examined the relationship between PA intensity, cognitive performance, and resting state functional connectivity in PD and whether PA intensity influences the relationship between functional connectivity and cognitive performance.

METHODS:

96 individuals with mild-moderate PD completed a comprehensive neuropsychological battery. Intensity of PA was objectively captured over a seven-day period using a wearable device (ActiGraph). Time spent in light and moderate intensity PA was determined based on standardized actigraphy cut points. Resting-state fMRI was assessed in a subset of 50 individuals to examine brain-wide functional connectivity.

RESULTS:

Moderate intensity PA (MIPA), but not light PA, was associated with better global cognition, visuospatial function, memory, and executive function. Individuals who met the WHO recommendation of ≥150 min/week of MIPA demonstrated better global cognition, executive function, and visuospatial function. Resting-state functional connectivity associated with MIPA included a combination of brainstem, hippocampus, and regions in the frontal, cingulate, and parietal cortices, which showed higher connectivity across the brain in those achieving the WHO MIPA recommendation. Meeting this recommendation positively moderated the associations between identified functional connectivity and global cognition, visuospatial function, and language.

CONCLUSION:

Encouraging MIPA, particularly the WHO recommendation of ≥150 min of MIPA/week, may represent an important prescription for PD cognition.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Cognitive Dysfunction Type of study: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Humans Language: En Journal: Parkinsonism Relat Disord Journal subject: NEUROLOGIA Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Cognitive Dysfunction Type of study: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Humans Language: En Journal: Parkinsonism Relat Disord Journal subject: NEUROLOGIA Year: 2022 Document type: Article Affiliation country: