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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Brinkhaus, Maximilian; Pannecoucke, Erwin; van der Kooi, Elvera J; Bentlage, Arthur E H; Derksen, Ninotska I L; Andries, Julie; Balbino, Bianca; Sips, Magdalena; Ulrichts, Peter; Verheesen, Peter; de Haard, Hans; Rispens, Theo; Savvides, Savvas N; Vidarsson, Gestur.
Affiliation
  • Brinkhaus M; Immunoglobulin Research Laboratory, Department of Experimental Immunohematology, Sanquin Research and Landsteiner, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • Pannecoucke E; Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.
  • van der Kooi EJ; argenx, 9052, Zwijnaarde, Belgium.
  • Bentlage AEH; argenx, 9052, Zwijnaarde, Belgium.
  • Derksen NIL; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
  • Andries J; Unit for Structural Biology, VIB-UGent Center for Inflammation Research, 9052, Ghent, Belgium.
  • Balbino B; Immunoglobulin Research Laboratory, Department of Experimental Immunohematology, Sanquin Research and Landsteiner, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • Sips M; Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.
  • Ulrichts P; Immunoglobulin Research Laboratory, Department of Experimental Immunohematology, Sanquin Research and Landsteiner, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • Verheesen P; Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.
  • de Haard H; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
  • Rispens T; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
  • Savvides SN; Unit for Structural Biology, VIB-UGent Center for Inflammation Research, 9052, Ghent, Belgium.
  • Vidarsson G; argenx, 9052, Zwijnaarde, Belgium.
Nat Commun ; 13(1): 6073, 2022 10 14.
Article in En | MEDLINE | ID: mdl-36241613
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: Country of publication: