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Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.
Heering, Jan; Jores, Nathalie; Kilu, Whitney; Schallmayer, Espen; Peelen, Evelyn; Muehler, Andreas; Kohlhof, Hella; Vitt, Daniel; Linhard, Verena; Gande, Santosh L; Chaikuad, Apirat; Sreeramulu, Sridhar; Schwalbe, Harald; Merk, Daniel.
Affiliation
  • Heering J; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, 60596Frankfurt, Germany.
  • Jores N; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany.
  • Kilu W; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany.
  • Schallmayer E; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany.
  • Peelen E; Immunic AG, 82166Gräfelfing, Germany.
  • Muehler A; Immunic AG, 82166Gräfelfing, Germany.
  • Kohlhof H; Immunic AG, 82166Gräfelfing, Germany.
  • Vitt D; Immunic AG, 82166Gräfelfing, Germany.
  • Linhard V; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany.
  • Gande SL; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany.
  • Chaikuad A; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany.
  • Sreeramulu S; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany.
  • Schwalbe H; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany.
  • Merk D; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany.
ACS Chem Biol ; 17(11): 3159-3168, 2022 11 18.
Article in En | MEDLINE | ID: mdl-36318238
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Acids and Salts / Receptors, Cytoplasmic and Nuclear Language: En Journal: ACS Chem Biol Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Acids and Salts / Receptors, Cytoplasmic and Nuclear Language: En Journal: ACS Chem Biol Year: 2022 Document type: Article Affiliation country: Country of publication: