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Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation.
Ahmed, Mustafa I; Andrikopoulou, Efstathia; Zheng, Jingyi; Ulasova, Elena; Pat, Betty; Kelley, Eric E; Powell, Pamela Cox; Denney, Thomas S; Lewis, Clifton; Davies, James E; Darley-Usmar, Victor; Dell'Italia, Louis J.
Affiliation
  • Ahmed MI; Division of Cardiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Andrikopoulou E; Division of Cardiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Zheng J; Department of Mathematics and Statistics, Auburn University, Auburn, Alabama, USA.
  • Ulasova E; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Pat B; Division of Cardiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Kelley EE; Birmingham Veterans Affairs Health Care System, Birmingham, Alabama, USA.
  • Powell PC; Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia, USA.
  • Denney TS; Division of Cardiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Lewis C; Birmingham Veterans Affairs Health Care System, Birmingham, Alabama, USA.
  • Davies JE; Samuel Ginn College of Engineering, Auburn University, Auburn, Alabama, USA.
  • Darley-Usmar V; Division of Thoracic and Cardiovascular Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Dell'Italia LJ; Division of Thoracic and Cardiovascular Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
JACC Basic Transl Sci ; 7(10): 973-981, 2022 Oct.
Article in En | MEDLINE | ID: mdl-36337921
Interstitial collagen loss and cardiomyocyte ultrastructural damage accounts for left ventricular (LV) sphericity and decrease in LV twist and circumferential strain. Normal LV diastolic function belies significantly abnormal left atrial (LA) function and early LV diastolic untwist rate. This underscores the complex interplay of LV and LA myocardial remodeling and function in the pathophysiology of primary mitral regurgitation. In this study, we connect LA function with LV systolic and diastolic myocardial remodeling and function using cardiac magnetic resonance tissue tagging in primary mitral regurgitation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2022 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2022 Document type: Article Affiliation country: Country of publication: