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An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M ß-lactamase drug-resistance enzymes.
Lu, Shuo; Hu, Liya; Lin, Hanfeng; Judge, Allison; Rivera, Paola; Palaniappan, Murugesan; Sankaran, Banumathi; Wang, Jin; Prasad, B V Venkataram; Palzkill, Timothy.
Affiliation
  • Lu S; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA.
  • Hu L; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Lin H; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA.
  • Judge A; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Rivera P; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA.
  • Palaniappan M; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
  • Sankaran B; Department of Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Wang J; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA.
  • Prasad BVV; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Palzkill T; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA. timothyp@bcm.edu.
Nat Commun ; 13(1): 6726, 2022 11 07.
Article in En | MEDLINE | ID: mdl-36344533
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Escherichia coli / Anti-Bacterial Agents Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Escherichia coli / Anti-Bacterial Agents Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: Country of publication: