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Neutralizing activity of African lineage Zika virus immune sera towards Asian lineage.
Marchi, Serena; Dragoni, Filippo; Boccuto, Adele; Idoko, Olubukola T; Zazzi, Maurizio; Sow, Samba; Diallo, Aldiouma; Viviani, Simonetta; Montomoli, Emanuele; Vicenti, Ilaria; Trombetta, Claudia Maria.
Affiliation
  • Marchi S; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. Electronic address: serena.marchi2@unisi.it.
  • Dragoni F; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Boccuto A; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Idoko OT; Medical Research Council Unit, The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia.
  • Zazzi M; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Sow S; Centre for Vaccine Development (CVD), Bamako, Mali.
  • Diallo A; IRD, VITROME, Dakar, Senegal.
  • Viviani S; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
  • Montomoli E; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy; VisMederi srl, Siena, Italy.
  • Vicenti I; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Trombetta CM; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Acta Trop ; 237: 106736, 2023 Jan.
Article in En | MEDLINE | ID: mdl-36374844
Genetic and phylogenetic studies indicated that Zika virus (ZIKV) has evolved into 2 major lineages, the African and Asian. However, ZIKV has been described as a single serotype. This study aimed at assessing the cross-neutralization between ZIKV African and Asian lineages strains. Sixthy-five samples collected in 2007 and 30 samples collected from the same subjects in 2011/2012 in West Africa and positive to neutralizing antibody against ZIKV MR-766 strain (African lineage) were tested against ZIKV H/PF/2013 strain (Asian lineage) by microneutralization assay. All samples showing neutralizing antibodies against MR-766 strain showed also neutralizing activity against H/PF/2013 strain, although with lower titers. This is consistent with about 120 amino acid differences between the two strains. Despite differences in the magnitude of neutralizing activity against different ZIKV strains, all samples showed neutralizing antibody titers considered to be protective.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zika Virus / Zika Virus Infection Limits: Humans Language: En Journal: Acta Trop Year: 2023 Document type: Article Country of publication:
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zika Virus / Zika Virus Infection Limits: Humans Language: En Journal: Acta Trop Year: 2023 Document type: Article Country of publication: