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Gem-Difluoroallylation of Aryl Sulfonium Salts.
Zhao, Yue; Empel, Claire; Liang, Wenjing; Koenigs, Rene M; Patureau, Frederic W.
Affiliation
  • Zhao Y; Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
  • Empel C; Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
  • Liang W; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
  • Koenigs RM; Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
  • Patureau FW; Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
Org Lett ; 24(48): 8753-8758, 2022 12 09.
Article in En | MEDLINE | ID: mdl-36440861
ABSTRACT
The unprecedented photochemical late-stage defluorinative gem-difluoroallylation of aryl sulfonium salts, which are formed site-selectively by direct C(sp2)─H functionalization, is herein disclosed. This method is distinguished by its mild reaction conditions, wide scope, and excellent site-selectivity. As showcase examples, a Flurbiprofen and Pyriproxyfen derivatives could be late stage C(sp2)─H gem-difluoroallylated with high yields. Experimental and computational investigations were conducted.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2022 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2022 Document type: Article Affiliation country: