Your browser doesn't support javascript.
loading
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Liang, Xiaomin; Wei, Yuding; Hou, Xingzi; Guo, Qiang; Liang, Hong; Zeng, Kewu; Tu, Pengfei; Zhang, Qingying.
Affiliation
  • Liang X; State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
  • Wei Y; State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
  • Hou X; State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
  • Guo Q; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.
  • Liang H; State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
  • Zeng K; State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
  • Tu P; State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
  • Zhang Q; State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China. Electronic address: qyzhang@bjmu.edu.cn.
Phytochemistry ; 206: 113530, 2023 Feb.
Article in En | MEDLINE | ID: mdl-36455653
Seven undescribed triterpenoids were obtained from the ethanol extract of the dried stems of Uncaria macrophylla Wall. (Rubiaceae).All of the isolates were urs-28-oic acid or olean-28-oic acid skeletons, including three triterpenoids with rare 3ß,23-(1R-4-hydroxy-butyl-1,1-dioxy) or 23-(2R-tetrahydrofuran-2-oxy) substituents. Five triterpenoids showed promising inhibitory activity against erastin-induced ferroptosis in PC12 cells, while 3ß,6α,23-trihydroxy-olean-12-en-28-oic acid was the most significant inhibitor to resist ferroptosis by activating the Nrf2/SLC7A11/GPx4 axis with an EC50 value of 4.2 ± 0.7 µM.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Uncaria / Ferroptosis Language: En Journal: Phytochemistry Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Uncaria / Ferroptosis Language: En Journal: Phytochemistry Year: 2023 Document type: Article Affiliation country: Country of publication: