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CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer's disease.
Lerner, Alan J; Arnold, Steven E; Maxfield, Erin; Koenig, Aaron; Toth, Maria E; Fortin, Brooke; Mast, Natalia; Trombetta, Bianca A; Denker, John; Pieper, Andrew A; Tatsuoka, Curtis; Raghupathy, Sangeetha; Pikuleva, Irina A.
Affiliation
  • Lerner AJ; Brain Health and Memory Center, Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44122, USA.
  • Arnold SE; Department of Neurology, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Maxfield E; Alzheimer's Clinical and Translational Research Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
  • Koenig A; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Toth ME; Alzheimer's Clinical and Translational Research Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
  • Fortin B; Brain Health and Memory Center, Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44122, USA.
  • Mast N; Alzheimer's Clinical and Translational Research Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
  • Trombetta BA; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Denker J; Alzheimer's Clinical and Translational Research Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
  • Pieper AA; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Tatsuoka C; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA.
  • Raghupathy S; Department of Psychiatry, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Pikuleva IA; Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, 44106, USA.
Alzheimers Res Ther ; 14(1): 198, 2022 12 29.
Article in En | MEDLINE | ID: mdl-36581878

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Alzheimers Res Ther Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Alzheimers Res Ther Year: 2022 Document type: Article Affiliation country: Country of publication: