Pulsatile gas-liquid flow resembling Decompression Sickness: Computational Fluid Dynamics simulation and experimental validation.

ABSTRACT

BACKGROUND: This work performs two-dimensional Computational Fluid Dynamics (CFD) simulations of pulsatile bubbly flow in a column resembling the flow inside human vena cava during Decompression Sickness (DCS), aiming to illustrate the effect of certain parameters in bubbly blood flow and so facilitate the design of the a) corresponding in-vitro bubbly flow experiments under pulsatile flow conditions inside a flow loop and b) in-vivo trials on swines for assessing a novel electrical impedance spectroscopy technique on the detection of bubbles (as those found during DCS) in their bloodstream. MATERIALS AND METHODS: The commercially available ANSYS 2019-R3 CFD code was employed to simulate the pulsatile bubbly flow that resembled DCS. Simulations were validated against experiments conducted in a vertical co-current upward pulsatile bubbly flow provided by a flow loop equipped with electrical, optical and pressure diagnostics. RESULTS: CFD simulations under pulsatile conditions were initially validated by oscillatory in-vitro bubbly flow experiments. Then, the influence of pulsation parameters on void fraction, α, and flow velocity, U, profiles was computationally investigated. Intense periodic fluctuations of void fraction were observed along the column and their intensity increases with pulsation amplitude. Moreover, U and α radial profiles were uniform for bubbles 30 µm but showed a core-peaking profile for bubbles 300 µm. CONCLUSIONS: CFD simulations of pulsatile bubbly flow resembling DCS provided unconventional information about the influence of different-sized sub-millimetre bubbles on the flow velocity and void fraction profiles, which are expected to improve the design of in-vitro and in-vivo trials for the detection of bubbles such as those found in DCS.