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Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mabanglo, Mark F; Wong, Keith S; Barghash, Marim M; Leung, Elisa; Chuang, Stephanie H W; Ardalan, Afshan; Majaesic, Emily M; Wong, Cassandra J; Zhang, Shen; Lang, Henk; Karanewsky, Donald S; Iwanowicz, Andrew A; Graves, Lee M; Iwanowicz, Edwin J; Gingras, Anne-Claude; Houry, Walid A.
Affiliation
  • Mabanglo MF; Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Wong KS; Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Barghash MM; Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Leung E; Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Chuang SHW; Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Ardalan A; Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Majaesic EM; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
  • Wong CJ; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON M5G 1X5, Canada.
  • Zhang S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON M5G 1X5, Canada; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, Hunan 410008, China.
  • Lang H; Madera Therapeutics LLC, Cary, NC 27513, USA.
  • Karanewsky DS; Madera Therapeutics LLC, Cary, NC 27513, USA.
  • Iwanowicz AA; Madera Therapeutics LLC, Cary, NC 27513, USA.
  • Graves LM; Department of Pharmacology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Iwanowicz EJ; Madera Therapeutics LLC, Cary, NC 27513, USA.
  • Gingras AC; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Houry WA; Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada. Electronic address: walid.houry@utoronto.ca.
Structure ; 31(2): 185-200.e10, 2023 02 02.
Article in En | MEDLINE | ID: mdl-36586405
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteomics / Mitochondria Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteomics / Mitochondria Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication: