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Highly inert Cu(II) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution.
Pineau, Julie; Lima, Luís M P; Le Roy, Marie M; Marionneau-Lambot, Séverine; Cordier, Marie; Le Saëc, Patricia; Zeevaart, Jan Rijn; Driver, Cathryn H S; Faivre-Chauvet, Alain; Le Bris, Nathalie; Tripier, Raphaël.
Affiliation
  • Pineau J; Univ Brest, CEMCA, UMR CNRS 6521, 6 Av. Victor le Gorgeu, Brest 29200, France. nathalie.lebris@univ-brest.fr.
  • Lima LMP; Nova University of Lisbon, ITQB, Av. da República, Oeiras 2780-157, Portugal.
  • Le Roy MM; Univ Brest, CEMCA, UMR CNRS 6521, 6 Av. Victor le Gorgeu, Brest 29200, France. nathalie.lebris@univ-brest.fr.
  • Marionneau-Lambot S; Univ Nantes, CRCI2NA, UMR INSERM 1307, UMR CNRS 6075, 8 Quai Moncousu, Nantes 44007, France.
  • Cordier M; Univ Rennes, ISCR, UMR CNRS 6226, 263 Av. Général Leclerc, Rennes 35000, France.
  • Le Saëc P; Univ Nantes, CRCI2NA, UMR INSERM 1307, UMR CNRS 6075, 8 Quai Moncousu, Nantes 44007, France.
  • Zeevaart JR; South African Nuclear Energy Corporation, Elias Motsoaledi Street, R104 Pelindaba, North West, 0240, South Africa.
  • Driver CHS; South African Nuclear Energy Corporation, Elias Motsoaledi Street, R104 Pelindaba, North West, 0240, South Africa.
  • Faivre-Chauvet A; Univ Nantes, CRCI2NA, UMR INSERM 1307, UMR CNRS 6075, 8 Quai Moncousu, Nantes 44007, France.
  • Le Bris N; Univ Brest, CEMCA, UMR CNRS 6521, 6 Av. Victor le Gorgeu, Brest 29200, France. nathalie.lebris@univ-brest.fr.
  • Tripier R; Univ Brest, CEMCA, UMR CNRS 6521, 6 Av. Victor le Gorgeu, Brest 29200, France. nathalie.lebris@univ-brest.fr.
Chem Commun (Camb) ; 59(7): 888-891, 2023 Jan 19.
Article in En | MEDLINE | ID: mdl-36598060
ABSTRACT
Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclams / Heterocyclic Compounds Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclams / Heterocyclic Compounds Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: