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IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts.
Picard, Felix Simon Ruben; Lutz, Veronika; Brichkina, Anna; Neuhaus, Felix; Ruckenbrod, Teresa; Hupfer, Anna; Raifer, Hartmann; Klein, Matthias; Bopp, Tobias; Pfefferle, Petra Ina; Savai, Rajkumar; Prinz, Immo; Waisman, Ari; Moos, Sonja; Chang, Hyun-Dong; Heinrich, Stefan; Bartsch, Detlef K; Buchholz, Malte; Singh, Shiv; Tu, Mengyu; Klein, Lukas; Bauer, Christian; Liefke, Robert; Burchert, Andreas; Chung, Ho-Ryun; Mayer, Philipp; Gress, Thomas M; Lauth, Matthias; Gaida, Matthias; Huber, Magdalena.
Affiliation
  • Picard FSR; Institute of Systems Immunology, Philipps-University Marburg, Marburg, Germany.
  • Lutz V; Institute of Systems Immunology, Philipps-University Marburg, Marburg, Germany.
  • Brichkina A; Department of Gastroenterology, Endocrinology, Metabolism and Infection, Center for Tumor and Immunology (ZTI), Philipps-University Marburg, Marburg, Germany.
  • Neuhaus F; Institute of Systems Immunology, Philipps-University Marburg, Marburg, Germany.
  • Ruckenbrod T; Institute of Systems Immunology, Philipps-University Marburg, Marburg, Germany.
  • Hupfer A; Department of Gastroenterology, Endocrinology, Metabolism and Infection, Center for Tumor and Immunology (ZTI), Philipps-University Marburg, Marburg, Germany.
  • Raifer H; Institute of Systems Immunology, Philipps-University Marburg, Marburg, Germany.
  • Klein M; Core-Facility Flow Cytometry, Philipps-University Marburg, Marburg, Germany.
  • Bopp T; Institute for Immunology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  • Pfefferle PI; Institute for Immunology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  • Savai R; Comprehensive Biomaterial Bank Marburg (CBBMR), Philipps-Universitat Marburg, Marburg, Germany.
  • Prinz I; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center, Justus Liebig Universitat, Giessen, Germany.
  • Waisman A; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
  • Moos S; Institute of Systems Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Chang HD; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
  • Heinrich S; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
  • Bartsch DK; Institute of Biotechnology, Technische Universität, Berlin, Germany.
  • Buchholz M; German Rheumatism Research Center (DRFZ), An Institute of the Leibniz Association, Berlin, Germany.
  • Singh S; Department of Surgery, Johannes Gutenberg University, Mainz, Germany.
  • Tu M; Division of Visceral, Thoracic and Vascular Surgery, Philipps-University Marburg, Marburg, Germany.
  • Klein L; Department of Gastroenterology, Endocrinology, Metabolism and Infection, Center for Tumor and Immunology (ZTI), Philipps-University Marburg, Marburg, Germany.
  • Bauer C; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany.
  • Liefke R; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany.
  • Burchert A; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany.
  • Chung HR; Department of Gastroenterology, Endocrinology, Metabolism and Infection, Center for Tumor and Immunology (ZTI), Philipps-University Marburg, Marburg, Germany.
  • Mayer P; Institute of Molecular Biology and Tumor Research (IMT), Philipps-University Marburg, Marburg, Germany.
  • Gress TM; Department of Hematology, Oncology and Immunology, Philipps University Marburg Faculty of Medicine, Marburg, Germany.
  • Lauth M; Institute for Medical Bioinformatics and Biostatistics, Philipps-University Marburg, Marburg, Germany.
  • Gaida M; Department of Diagnostic and Interventional Radiology, Heidelberg University, Heidelberg, Germany.
  • Huber M; Department of Gastroenterology, Endocrinology, Metabolism and Infection, Center for Tumor and Immunology (ZTI), Philipps-University Marburg, Marburg, Germany.
Gut ; 72(8): 1510-1522, 2023 Aug.
Article in En | MEDLINE | ID: mdl-36759154

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Pancreatic Ductal / Cancer-Associated Fibroblasts Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Gut Year: 2023 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Carcinoma, Pancreatic Ductal / Cancer-Associated Fibroblasts Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Gut Year: 2023 Document type: Article Affiliation country: