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Advancing targeted protein degrader discovery by measuring cereblon engagement in cells.
Zerfas, Breanna L; Huerta, Fidel; Liu, Hu; Du, Guangyan; Gray, Nathanael S; Jones, Lyn H; Nowak, Radoslaw P.
Affiliation
  • Zerfas BL; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States. Electronic address: breannal_zerfas@dfci.harvard.edu.
  • Huerta F; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, MA, United States.
  • Liu H; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.
  • Du G; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.
  • Gray NS; Department of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, United States.
  • Jones LH; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States. Electronic address: lyn_jones@dfci.harvard.edu.
  • Nowak RP; Center for Protein Degradation, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States. Electronic address: radoslawp_nowak@dfci.harvard.edu.
Methods Enzymol ; 681: 169-188, 2023.
Article in En | MEDLINE | ID: mdl-36764756
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases Language: En Journal: Methods Enzymol Year: 2023 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases Language: En Journal: Methods Enzymol Year: 2023 Document type: Article Country of publication: