Inferring Gene Regulatory Networks and Predicting the Effect of Gene Perturbations via IQCELL.
Methods Mol Biol
; 2767: 251-262, 2024.
Article
in En
| MEDLINE
| ID: mdl-36790623
ABSTRACT
IQCELL is a platform that infers Boolean gene regulatory networks from single-cell RNA sequencing data. Boolean networks can be simulated under normal and perturbed conditions. In this chapter, we provide a detailed guideline for implementing IQCELL from a raw dataset. The steps include processing data, inferring informative genes, inferring gene regulatory network, and simulating the resulted network under normal and perturbed conditions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Algorithms
/
Gene Regulatory Networks
Type of study:
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
Methods Mol Biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2024
Document type:
Article
Affiliation country: