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NR3C1 gene methylation and cortisol levels in preterm and healthy full-term infants in the first 3 months of life.
Chalfun, Georgia; Araújo Brasil, Aline de; Paravidino, Vitor Barreto; Soares-Lima, Sheila Coelho; Souza Almeida Lopes, Monique de; Santos Salú, Margarida Dos; Barbosa E Dos Santos, Paulo Victor; P da Cunha Trompiere, Ana Carolina; Vieira Milone, Leo Travassos; Rodrigues-Santos, Gustavo; Genuíno de Oliveira, Mariana Barros; Robaina, Jaqueline Rodrigues; Lima-Setta, Fernanda; Reis, Marcelo Martins; Ledo Alves da Cunha, Antônio José; Prata-Barbosa, Arnaldo; de Magalhães-Barbosa, Maria Clara.
Affiliation
  • Chalfun G; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Araújo Brasil A; Department of Neonatology, Maternity School, Federal University of Rio de Janeiro (UFRJ), RJ, 22240-000, Brazil.
  • Paravidino VB; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Soares-Lima SC; Department of Epidemiology, Institute of Social Medicine, University of the State of Rio de Janeiro (UERJ), 20550-013, Brazil.
  • Souza Almeida Lopes M; Department of Physical Education & Sports, Naval Academy, Brazilian Navy, Rio de Janeiro, RJ, 20021-010, Brazil.
  • Santos Salú MD; Molecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro, RJ, 20230-130, Brazil.
  • Barbosa E Dos Santos PV; Molecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro, RJ, 20230-130, Brazil.
  • P da Cunha Trompiere AC; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Vieira Milone LT; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Rodrigues-Santos G; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Genuíno de Oliveira MB; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Robaina JR; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Lima-Setta F; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Reis MM; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Ledo Alves da Cunha AJ; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • Prata-Barbosa A; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
  • de Magalhães-Barbosa MC; Department of Pediatrics, D'Or Institute for Research & Education (IDOR), Rio de Janeiro, RJ, 22281-100, Brazil.
Epigenomics ; 14(24): 1545-1561, 2022 12.
Article in En | MEDLINE | ID: mdl-36861354
We investigated the methylation of a gene, NR3C1 exon-1F, and cortisol levels in newborns. DNA methylation is a biochemical process that can modify gene activity. In the case of this gene, higher methylation might be associated with higher cortisol levels. We studied 46 preterm infants (born weighing 1500 g or less) and 49 full-term infants. Our results revealed that the preterm infants had hypermethylation at birth and higher cortisol levels on day 5, but decreasing methylation and stable cortisol levels over time. Meanwhile, methylation remained stable and cortisol levels increased in full-term babies with time. These unexpected results suggest that prematurity can be associated with prenatal epigenetic changes in the NR3C1 gene, but postnatal factors may induce further modifications. More research is needed to understand these findings better.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Infant, Premature / DNA Methylation Limits: Female / Humans / Infant / Newborn / Pregnancy Language: En Journal: Epigenomics Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Infant, Premature / DNA Methylation Limits: Female / Humans / Infant / Newborn / Pregnancy Language: En Journal: Epigenomics Year: 2022 Document type: Article Affiliation country: Country of publication: