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The interweaved signatures of common-gamma-chain cytokines across immunologic lineages.
Baysoy, Alev; Seddu, Kumba; Salloum, Tamara; Dawson, Caleb A; Lee, Juliana J; Yang, Liang; Gal-Oz, Shani; Ner-Gaon, Hadas; Tellier, Julie; Millan, Alberto; Sasse, Alexander; Brown, Brian; Lanier, Lewis L; Shay, Tal; Nutt, Stephen; Dwyer, Daniel; Benoist, Christophe.
Affiliation
  • Baysoy A; Department of Immunology, Harvard Medical School , Boston, MA, USA.
  • Seddu K; Broad Institute of MIT and Harvard , Cambridge, MA, USA.
  • Salloum T; Department of Immunology, Harvard Medical School , Boston, MA, USA.
  • Dawson CA; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital; and Department of Medicine, Harvard Medical School , Boston, MA, USA.
  • Lee JJ; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne , Parkville, Australia.
  • Yang L; Department of Immunology, Harvard Medical School , Boston, MA, USA.
  • Gal-Oz S; Department of Immunology, Harvard Medical School , Boston, MA, USA.
  • Ner-Gaon H; Department of Life Sciences, Ben-Gurion University of the Negev , Beer-Sheva, Israel.
  • Tellier J; Department of Life Sciences, Ben-Gurion University of the Negev , Beer-Sheva, Israel.
  • Millan A; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne , Parkville, Australia.
  • Sasse A; Department of Microbiology and Immunology, University of California, San Francisco , San Francisco, CA, USA.
  • Brown B; Paul G. Allen School of Computer Science and Engineering, University of Washington , Seattle, WA, USA.
  • Lanier LL; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai , New York, NY, USA.
  • Shay T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY, USA.
  • Nutt S; Department of Microbiology and Immunology, University of California, San Francisco , San Francisco, CA, USA.
  • Dwyer D; Department of Life Sciences, Ben-Gurion University of the Negev , Beer-Sheva, Israel.
  • Benoist C; The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne , Parkville, Australia.
J Exp Med ; 220(7)2023 07 03.
Article in En | MEDLINE | ID: mdl-36976164
ABSTRACT
"γc" cytokines are a family whose receptors share a "common-gamma-chain" signaling moiety, and play central roles in differentiation, homeostasis, and communications of all immunocyte lineages. As a resource to better understand their range and specificity of action, we profiled by RNAseq the immediate-early responses to the main γc cytokines across all immunocyte lineages. The results reveal an unprecedented landscape broader, with extensive overlap between cytokines (one cytokine doing in one cell what another does elsewhere) and essentially no effects unique to any one cytokine. Responses include a major downregulation component and a broad Myc-controlled resetting of biosynthetic and metabolic pathways. Various mechanisms appear involved fast transcriptional activation, chromatin remodeling, and mRNA destabilization. Other surprises were uncovered IL2 effects in mast cells, shifts between follicular and marginal zone B cells, paradoxical and cell-specific cross-talk between interferon and γc signatures, or an NKT-like program induced by IL21 in CD8+ T cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / CD8-Positive T-Lymphocytes Language: En Journal: J Exp Med Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / CD8-Positive T-Lymphocytes Language: En Journal: J Exp Med Year: 2023 Document type: Article Affiliation country: