The interweaved signatures of common-gamma-chain cytokines across immunologic lineages.
J Exp Med
; 220(7)2023 07 03.
Article
in En
| MEDLINE
| ID: mdl-36976164
ABSTRACT
"γc" cytokines are a family whose receptors share a "common-gamma-chain" signaling moiety, and play central roles in differentiation, homeostasis, and communications of all immunocyte lineages. As a resource to better understand their range and specificity of action, we profiled by RNAseq the immediate-early responses to the main γc cytokines across all immunocyte lineages. The results reveal an unprecedented landscape broader, with extensive overlap between cytokines (one cytokine doing in one cell what another does elsewhere) and essentially no effects unique to any one cytokine. Responses include a major downregulation component and a broad Myc-controlled resetting of biosynthetic and metabolic pathways. Various mechanisms appear involved fast transcriptional activation, chromatin remodeling, and mRNA destabilization. Other surprises were uncovered IL2 effects in mast cells, shifts between follicular and marginal zone B cells, paradoxical and cell-specific cross-talk between interferon and γc signatures, or an NKT-like program induced by IL21 in CD8+ T cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cytokines
/
CD8-Positive T-Lymphocytes
Language:
En
Journal:
J Exp Med
Year:
2023
Document type:
Article
Affiliation country: