Mild SARS-CoV-2 infection in vulnerable patients: implementation of a clinical pathway for early treatment.
Enferm Infecc Microbiol Clin (Engl Ed)
; 42(4): 195-201, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-37003904
ABSTRACT
INTRODUCTION:
The objective of this report is to describe the clinical pathway for early treatment of patients with acute SARS-CoV-2 infection and to evaluate the first results of its implementation.METHODS:
This is a descriptive and retrospective study of the implementation of a clinical pathway of treatment in outpatients (January 1 to June 30 2022). Clinical pathway detection and referral systems from Primary Care, Emergency services, hospital specialities and an automated detection system; clinical evaluation and treatment administration in the COVID-19 day-hospital and subsequent clinical follow-up. Explanatory variables demographics, comorbidity, vaccination status, referral pathways and treatment administration. OUTCOME VARIABLES hospitalization and death with 30 days, grade 2-3 toxicity related to treatment.RESULTS:
Treatment was administered to 262 patients (53,4% women, median age 60 years). The treatment indication criteria were immunosupression (68,3%), and the combination of age, vaccination status and comorbidity in the rest 47,3% of the patients s received remdesivir, 35,9% nirmatrelvir/ritonavir, 13,4% sotrovimab and 2,4% combined treatment with a median of 4 days after symptom onset. Hospital admission was required for 6,1% of the patients, 3,8% related to progression COVID-19. No patient died. Toxicity grade 2-3 toxicity was reported in 18,7%, 89,8% dysgeusia and metallic tasted related nirmatrelvir/ritonavir. Seven patients discontinued treatment due to toxicity.CONCLUSION:
The creation and implementation of a clinical pathway for non-hospitalized patients with SARS-CoV-2 infection is effective and it allows early accessibility and equity of currently available treatments.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proline
/
Critical Pathways
/
COVID-19
/
Lactams
/
Leucine
/
Nitriles
Type of study:
Guideline
/
Observational_studies
Limits:
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Language:
En
Journal:
Enferm Infecc Microbiol Clin (Engl Ed)
Year:
2024
Document type:
Article
Affiliation country: