Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
Curr Med Sci
; 43(2): 399-408, 2023 Apr.
Article
in En
| MEDLINE
| ID: mdl-37017855
ABSTRACT
OBJECTIVE:
Psoriasis is often combined with metabolic abnormalities, such as obesity and diabetes. The upregulation of chemerin, which is an essential protein produced primarily from white fat, is strongly correlated to the development of psoriasis. However, there is no clarification on its exact function and mechanism in disease pathogenesis. The present study aims to determine its function and mechanism in disease pathogenesis.METHODS:
The present study used a psoriasislike inflammatory cell model and imiquimod (IMQ)-induced mouse model to confirm whether chemerin is upregulated in psoriasis patients.RESULTS:
Chemerin enhanced the keratinocyte proliferation, inflammatory cytokine secretion, and activation of the MAPK signaling pathway. Crucially, the intraperitoneal injection of neutralizing anti-chemerin antibody (ChAb) diminished the epidermal proliferation and inflammation in the IMQ-induced mouse model.CONCLUSION:
The present results indicate that chemerin promotes keratinocyte proliferation, and enhances the production of inflammatory cytokines, thereby aggravating the psoriasis. Thus, chemerin can be a prospective target for the treatment of psoriasis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psoriasis
Limits:
Animals
Language:
En
Journal:
Curr Med Sci
Year:
2023
Document type:
Article
Affiliation country: