Structural mechanism of a drug-binding process involving a large conformational change of the protein target.

Ayaz, Pelin; Lyczek, Agatha; Paung, YiTing; Mingione, Victoria R; Iacob, Roxana E; de Waal, Parker W; Engen, John R; Seeliger, Markus A; Shan, Yibing; Shaw, David E

Ayaz, Pelin; Lyczek, Agatha; Paung, YiTing; Mingione, Victoria R; Iacob, Roxana E; de Waal, Parker W; Engen, John R; Seeliger, Markus A; Shan, Yibing; Shaw, David E.

Affiliation

Ayaz P; D. E. Shaw Research, New York, NY, 10036, USA.
Lyczek A; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY, 11794-8651, USA.
Paung Y; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY, 11794-8651, USA.
Mingione VR; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY, 11794-8651, USA.
Iacob RE; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
de Waal PW; Relay Therapeutics, 399 Binney St., Cambridge, MA, 02139, USA.
Engen JR; D. E. Shaw Research, New York, NY, 10036, USA.
Seeliger MA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
Shan Y; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY, 11794-8651, USA. Markus.Seeliger@stonybrook.edu.
Shaw DE; D. E. Shaw Research, New York, NY, 10036, USA. Yibing.Shan@DEShawResearch.com.

Nat Commun ; 14(1): 1885, 2023 04 05.

Article in En | MEDLINE | ID: mdl-37019905

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Antineoplastic Agents Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Country of publication:

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