Alkaloids and Polyacetylenes from Hippobroma longiflora with Antiangiogenesis Properties.
J Nat Prod
; 86(4): 719-729, 2023 04 28.
Article
in En
| MEDLINE
| ID: mdl-37023532
Four new alkaloids, hippobrines A-D (1-4), along with three new polyacetylenes, hippobrenes A-C (5-7), were isolated from Hippobroma longiflora. Compounds 1-3 possess an unprecedented carbon skeleton. All of the new structures were determined by analyzing their mass and NMR spectroscopic data. The absolute configurations of 1 and 2 were confirmed by single-crystal X-ray analyses, and the absolute configurations of 3 and 7 were deduced using their ECD spectra. Plausible biogenetic pathways of 1 and 4 were proposed. In regard to bioactivities, all compounds (1-7) exhibited weak antiangiogenic activity against human endothelial progenitor cells, with IC50 values ranging from 21.1 ± 1.1 to 44.0 ± 2.3 µg/mL.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alkaloids
Limits:
Humans
Language:
En
Journal:
J Nat Prod
Year:
2023
Document type:
Article
Affiliation country:
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