Your browser doesn't support javascript.
loading
Alkaloids and Polyacetylenes from Hippobroma longiflora with Antiangiogenesis Properties.
Ke, Tzu-Yi; Wang, Shih-Wei; Chen, Shu-Rong; Huang, Dong-Ming; Lin, Yun-Sheng; Hwang, Tsong-Long; Sun, Wen-Chun; Cheng, Yuan-Bin.
Affiliation
  • Ke TY; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
  • Wang SW; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
  • Chen SR; Institute of Biomedical Sciences, MacKay Medical College, New Taipei City 25245, Taiwan.
  • Huang DM; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan.
  • Lin YS; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
  • Hwang TL; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
  • Sun WC; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan.
  • Cheng YB; Department of Biological Science and Technology, Meiho University, Pingtung 91202, Taiwan.
J Nat Prod ; 86(4): 719-729, 2023 04 28.
Article in En | MEDLINE | ID: mdl-37023532
Four new alkaloids, hippobrines A-D (1-4), along with three new polyacetylenes, hippobrenes A-C (5-7), were isolated from Hippobroma longiflora. Compounds 1-3 possess an unprecedented carbon skeleton. All of the new structures were determined by analyzing their mass and NMR spectroscopic data. The absolute configurations of 1 and 2 were confirmed by single-crystal X-ray analyses, and the absolute configurations of 3 and 7 were deduced using their ECD spectra. Plausible biogenetic pathways of 1 and 4 were proposed. In regard to bioactivities, all compounds (1-7) exhibited weak antiangiogenic activity against human endothelial progenitor cells, with IC50 values ranging from 21.1 ± 1.1 to 44.0 ± 2.3 µg/mL.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkaloids Limits: Humans Language: En Journal: J Nat Prod Year: 2023 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkaloids Limits: Humans Language: En Journal: J Nat Prod Year: 2023 Document type: Article Affiliation country: Country of publication: