Application of systemic inflammation indices and lipid metabolism-related factors in coronary artery disease.
Coron Artery Dis
; 34(5): 306-313, 2023 08 01.
Article
in En
| MEDLINE
| ID: mdl-37102240
ABSTRACT
OBJECTIVE:
We aimed to investigate the relationship between coronary artery disease (CAD) and systemic inflammation indices and lipid metabolism-related factors and subsequently, discuss the clinical application of these factors in CAD.METHODS:
We enrolled 284 consecutive inpatients with suspected CAD and divided them into a CAD group and a non-CAD group according to coronary angiography results. Serum levels of angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding protein 4 (FABP4), and tumor necrosis factor-α (TNF-α) levels were assessed using the ELISA and the systemic inflammation indices were calculated. Multivariate logistic regression was used to assess the risk factors of CAD. The receiver operating characteristic curve was used to determine the cutoff and diagnostic values.RESULTS:
The neutrophil-to-high density lipoprotein cholesterol ratio (5.04 vs. 3.47), neutrophil-to-lymphocyte ratio (3.25 vs. 2.45), monocyte-to-high density lipoprotein cholesterol ratio (MHR) (0.46 vs. 0.36), monocyte-to-lymphocyte ratio (0.31 vs. 0.26), systemic immune-inflammation index (SII) (696.00 vs. 544.82), serum TNF-α (398.15â ng/l vs. 350.65â ng/l), FABP4 (1644.00â ng/l vs. 1553.00â ng/l), ANGPTL3 (57.60â ng/ml vs. 52.85â ng/ml), and ANGPTL4 (37.35â ng/ml vs. 35.20â ng/ml) values showed a significant difference between the CAD and non-CAD groups ( P â <â 0.05). After adjusting for confounding factors, the following values were obtained ANGPTL3â >â 67.53â ng/ml [odds ratio (OR)â =â 8.108, 95% confidence interval (CI) (1.022-65.620)]; ANGPTL4â >â 29.95â ng/ml [ORâ =â 5.599, 95% CI (1.809-17.334)]; MHRâ >â 0.47 [ORâ =â 4.872, 95% CI (1.715-13.835)]; SIIâ >â 589.12 [ORâ =â 5.131, 95% CI (1.995-13.200)]. These factors were found to be independently associated with CAD ( P â <â 0.05). Diabetes combined with MHRâ >â 0.47, SIIâ >â 589.12, TNF-α >285.60â ng/l, ANGPTL3â >â 67.53â ng/ml, and ANGPTL4â >â 29.95â ng/l had the highest diagnostic value for CAD [area under the curve 0.921, 95% CI, (0.881-0.960), Sensitivity 88.9%, Specificity 82.2%, P â <â 0.001].CONCLUSION:
MHRâ >â 0.47, SIIâ >â 589.12, TNF-α >285.60â ng/l, ANGPTL3â >â 67.53â ng/ml, and ANGPTL4â >â 29.95â ng/l were identified as independent CAD risk factors and have valuable clinical implications in the diagnosis and treatment of CAD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronary Artery Disease
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Coron Artery Dis
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2023
Document type:
Article
Affiliation country: