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Application of systemic inflammation indices and lipid metabolism-related factors in coronary artery disease.
Zhao, Zhuoyan; Lian, Huan; Liu, Yixiang; Sun, Lixian; Zhang, Ying.
Affiliation
  • Zhao Z; Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Coron Artery Dis ; 34(5): 306-313, 2023 08 01.
Article in En | MEDLINE | ID: mdl-37102240
ABSTRACT

OBJECTIVE:

We aimed to investigate the relationship between coronary artery disease (CAD) and systemic inflammation indices and lipid metabolism-related factors and subsequently, discuss the clinical application of these factors in CAD.

METHODS:

We enrolled 284 consecutive inpatients with suspected CAD and divided them into a CAD group and a non-CAD group according to coronary angiography results. Serum levels of angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding protein 4 (FABP4), and tumor necrosis factor-α (TNF-α) levels were assessed using the ELISA and the systemic inflammation indices were calculated. Multivariate logistic regression was used to assess the risk factors of CAD. The receiver operating characteristic curve was used to determine the cutoff and diagnostic values.

RESULTS:

The neutrophil-to-high density lipoprotein cholesterol ratio (5.04 vs. 3.47), neutrophil-to-lymphocyte ratio (3.25 vs. 2.45), monocyte-to-high density lipoprotein cholesterol ratio (MHR) (0.46 vs. 0.36), monocyte-to-lymphocyte ratio (0.31 vs. 0.26), systemic immune-inflammation index (SII) (696.00 vs. 544.82), serum TNF-α (398.15 ng/l vs. 350.65 ng/l), FABP4 (1644.00 ng/l vs. 1553.00 ng/l), ANGPTL3 (57.60 ng/ml vs. 52.85 ng/ml), and ANGPTL4 (37.35 ng/ml vs. 35.20 ng/ml) values showed a significant difference between the CAD and non-CAD groups ( P  < 0.05). After adjusting for confounding factors, the following values were obtained ANGPTL3 > 67.53 ng/ml [odds ratio (OR) = 8.108, 95% confidence interval (CI) (1.022-65.620)]; ANGPTL4 > 29.95 ng/ml [OR = 5.599, 95% CI (1.809-17.334)]; MHR > 0.47 [OR = 4.872, 95% CI (1.715-13.835)]; SII > 589.12 [OR = 5.131, 95% CI (1.995-13.200)]. These factors were found to be independently associated with CAD ( P  < 0.05). Diabetes combined with MHR > 0.47, SII > 589.12, TNF-α >285.60 ng/l, ANGPTL3 > 67.53 ng/ml, and ANGPTL4 > 29.95 ng/l had the highest diagnostic value for CAD [area under the curve 0.921, 95% CI, (0.881-0.960), Sensitivity 88.9%, Specificity 82.2%, P  < 0.001].

CONCLUSION:

MHR > 0.47, SII > 589.12, TNF-α >285.60 ng/l, ANGPTL3 > 67.53 ng/ml, and ANGPTL4 > 29.95 ng/l were identified as independent CAD risk factors and have valuable clinical implications in the diagnosis and treatment of CAD.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronary Artery Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Coron Artery Dis Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2023 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronary Artery Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Coron Artery Dis Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2023 Document type: Article Affiliation country: