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Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells.
Kojima, Marenori; Suzuki, Katsuya; Takeshita, Masaru; Ohyagi, Masaki; Iizuka, Mana; Yamane, Humitsugu; Koga, Keiko; Kouro, Taku; Kassai, Yoshiaki; Yoshihara, Tomoki; Adachi, Ryutaro; Hashikami, Kentarou; Ota, Yuichiro; Yoshimoto, Keiko; Kaneko, Yuko; Morita, Rimpei; Yoshimura, Akihiko; Takeuchi, Tsutomu.
Affiliation
  • Kojima M; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Suzuki K; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Takeshita M; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Ohyagi M; Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Iizuka M; Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Yamane H; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Koga K; Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
  • Kouro T; Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
  • Kassai Y; Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
  • Yoshihara T; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
  • Adachi R; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
  • Hashikami K; Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
  • Ota Y; Axcelead Drug Discovery Partners, Inc., Fujisawa City, Kanagawa, Japan.
  • Yoshimoto K; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Kaneko Y; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Morita R; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Yoshimura A; Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Takeuchi T; Department of Microbiology and Immunology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Commun Biol ; 6(1): 500, 2023 05 09.
Article in En | MEDLINE | ID: mdl-37161050
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / T-Lymphocytes, Regulatory Limits: Animals Language: En Journal: Commun Biol Year: 2023 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / T-Lymphocytes, Regulatory Limits: Animals Language: En Journal: Commun Biol Year: 2023 Document type: Article Affiliation country: Country of publication: