Prognostic value of pre-treatment PNH clone among the patients with aplastic anemia: a meta-analysis.
Hematology
; 28(1): 2204617, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-37191286
ABSTRACT
BACKGROUND:
Paroxysmal nocturnal hemoglobinuria (PNH) clone can be detected in some patients with aplastic anemia (AA) before treatment. But the prognostic value of the presence of pre-treatment PNH clone for intensive immunosuppressive therapy (IIST) is controversial and no consensus on whether the occurrence of PNH/AA-PNH syndrome is related to pre-treatment PNH clone.OBJECTIVE:
This study aims to summarize the prognostic value of the presence of pre-treatment PNH clone treated with IIST among the AA patients and to elucidate its relationship with the development of PNH / AA-PNH syndrome.METHODS:
All published studies on the prognostic value of pre-treatment PNH clone among AA patients were retrieved. Pooled odds ratio (OR) was calculated to compare the rates, along with 95% confidence intervals (CI) and p value to assess whether the results were statistically significant.RESULTS:
The meta-analysis consisted of 15 studies with a combined total of 1349 patients in the cohort. Pre-treatment PNH clone had a positive effect on AA patients 6-month (pooled OR = 1.49,95% Cl 1.06-2.08, P = 0.020), 12-month (pooled OR = 3.10,95% Cl 1.89-5.10, P = 0.000), and overall hematological response rate (pooled OR = 1.69,95% Cl 1.07-2.68, P = 0.024) after IIST. Patients with pre-treatment PNH clone are more likely to develop PNH/AA-PNH syndrome after IIST(pooled OR = 2.78,95%Cl1.21-6.39, P = 0.016).CONCLUSION:
Patients with positive pre-treatment PNH clone had better hematological responses to IIST than negative. And, those patients are more likely to develop PNH/AA-PNH syndrome after IIST.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hemoglobinuria, Paroxysmal
/
Anemia, Aplastic
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Hematology
Journal subject:
HEMATOLOGIA
Year:
2023
Document type:
Article