Pregnancy in primary immunodeficiency diseases: The PREPI study.
J Allergy Clin Immunol
; 152(3): 760-770, 2023 09.
Article
in En
| MEDLINE
| ID: mdl-37210041
ABSTRACT
BACKGROUND:
Primary immunodeficiencies (PID) are a heterogeneous group of rare inborn immunity defects. As management has greatly improved, morbidity and mortality are reduced in this population, while our knowledge on pregnancy's unfolding and outcome remains scarce.OBJECTIVE:
We conducted a retrospective monocentric study to study pregnancy outcomes in women with PID.METHODS:
The study cohort consisted of women over 18 included in the national registry for PID (CEREDIH), living in the greater Paris area, reporting ≥1 pregnancy. Data were collected through a standardized questionnaire and medical records. We analyzed PID features, pregnancy course and outcome, and neonatal features (NCT04581460).RESULTS:
We studied 93 women with PID (27 combined immunodeficiencies, 51 predominantly antibody deficiencies, and 15 innate immunodeficiencies) and their 222 pregnancies (67, 119, and 36 in each group, respectively). One hundred fifty-four (69%) of 222 pregnancies led to 157 live births, including 4 severe preterm births (3%), in the range of pregnancy outcome in the French general population. In a multivariate model, poor obstetrical outcome (fetal loss or pregnancy termination) was associated with history of severe infection (adjusted odds ratio 0.28, 95% confidence interval 0.11-0.67, P = .005). Only 59% pregnancies were led with optimal anti-infective prophylaxis; severe infections were reported in only 2 pregnancies (1%). One infant died during the neonatal period.CONCLUSION:
Pregnancy is achievable in women with a wide group of PID. Prematurity is increased and history of severe infection is associated with significant increase of fetal loss/pregnancy termination. Adjustment of care during pregnancy needs to be better delivered.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Primary Immunodeficiency Diseases
/
Immunologic Deficiency Syndromes
/
Infant, Newborn, Diseases
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Infant
/
Newborn
/
Pregnancy
Language:
En
Journal:
J Allergy Clin Immunol
Year:
2023
Document type:
Article
Affiliation country: