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Risk of lymph node metastasis and feasibility of endoscopic submucosal dissection in undifferentiated-type early gastric cancer.
Zhang, Pengyue; Xu, Tingting; Feng, Hui; Zhu, Zhen; Wang, Jingjing; Wang, Yalei.
Affiliation
  • Zhang P; Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
  • Xu T; Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
  • Feng H; Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
  • Zhu Z; Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
  • Wang J; Department of Gastroenterology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
  • Wang Y; Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
BMC Gastroenterol ; 23(1): 175, 2023 May 23.
Article in En | MEDLINE | ID: mdl-37221499
BACKGROUND: Whether endoscopic submucosal dissection (ESD) applies to undifferentiated-type early gastric cancer (UEGC) remains controversial. We aimed to analyze the risk factors for lymph node metastasis (LNM) in UEGC and evaluate the feasibility of ESD. METHODS: This study included 346 patients with UEGC who underwent curative gastrectomy between January 2014 and December 2021. Univariate and multivariate analyses of the correlation between clinicopathological features and LNM were conducted, and the risk factors for exceeding the expanded ESD indications were evaluated. RESULTS: The overall LNM rate in UEGC was 19.94%. Among the preoperatively assessable factors, submucosal invasion (odds ratio [OR] = 4.77, 95% confidence interval [CI]: 2.14-10.66) and > 2 cm(OR = 2.49, 95% CI: 1.20-5.15) were independent risk factors for LNM, while postoperative independent risk factors were > 2 cm (OR = 3.35, 95% CI: 1.02-5.40) and lymphovascular invasion(OR = 13.21, 95% CI: 5.18-33.70). Patients who met the expanded indications had a low LNM risk (4.1%). Additionally, tumors located in the cardia (P = 0.03), non-elevated type (P < 0.01) were independent risk factors for exceeding the expanded indications in UEGC. CONCLUSIONS: ESD may be applicable for UEGC meeting the expanded indications, and preoperative evaluation should be cautious when the lesion is non-elevated type or located in the cardia. TRIAL REGISTRATION: Chinese Clinical Trial Registry (12/05/2022 ChiCTR2200059841 ).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Endoscopic Mucosal Resection Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: BMC Gastroenterol Journal subject: GASTROENTEROLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Endoscopic Mucosal Resection Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: BMC Gastroenterol Journal subject: GASTROENTEROLOGIA Year: 2023 Document type: Article Affiliation country: Country of publication: