BCG-Induced Immune Training: Interplay between Trained Immunity and Emergency Granulopoiesis.
J Mol Biol
; 435(15): 168169, 2023 08 01.
Article
in En
| MEDLINE
| ID: mdl-37263392
ABSTRACT
Bacille Calmette-Guérin (BCG) is the most commonly administered vaccine in human history. The medical application of BCG extends far beyond the fight against tuberculosis. Despite its stellar medical record over 100â¯years, insight into how BCG provides this vast range of benefits is largely limited, both for its pathogen-specific (tuberculosis) as well as pathogen-agnostic (other infections, autoimmunity, allergies, and cancer) effects. Trained immunity and emergency granulopoiesis have been identified as mediating BCG's pathogen-agnostic effects, for which some of the molecular mechanisms have been delineated. Upon review of the existing evidence, we postulate that emergency granulopoiesis and trained immunity are a continuum of the same effect cascade. In this context, we highlight that BCG's pathogen-agnostic benefits could be optimized by taking advantage of the age of the recipient and route of BCG administration.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis
/
BCG Vaccine
/
Trained Immunity
/
Hematopoiesis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Mol Biol
Year:
2023
Document type:
Article