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A Case Report of Mediastinal Teratoma in a Pediatric Patient With Nephrotic Syndrome: Paraneoplastic Syndrome or Incidental Finding?
Alva, Heather L; Ahn, Haejun; Zhao, Xixi; Obeidat, Mohammad; Charu, Vivek; Crane, Jacquelyn N; Marsenic, Olivera.
Affiliation
  • Alva HL; Division of Pediatric Hematology, Department of Pediatrics, Oncology, Stem Cell Transplantation and Regenerative Medicine.
  • Ahn H; Division of Pediatric Nephrology; Department of Pediatrics.
  • Zhao X; Division of Nephrology, Division of Pediatric Nephrology, Department of Medicine and Pediatrics.
  • Obeidat M; Department of Pathology, Stanford University School of Medicine, Palo Alto, CA.
  • Charu V; Department of Pathology, Stanford University School of Medicine, Palo Alto, CA.
  • Crane JN; Division of Pediatric Hematology, Department of Pediatrics, Oncology, Stem Cell Transplantation and Regenerative Medicine.
  • Marsenic O; Division of Pediatric Nephrology; Department of Pediatrics.
J Pediatr Hematol Oncol ; 45(5): e631-e634, 2023 07 01.
Article in En | MEDLINE | ID: mdl-37278520
A 12-year-old female presented with weight gain, edema, and shortness of breath. Laboratory and urine studies confirmed nephrotic syndrome and presence of a mediastinal mass, identified as a mature teratoma after resection. Nephrotic syndrome persisted despite resection and renal biopsy confirmed minimal change disease, which ultimately responded to steroid treatment. She had two relapses of nephrotic syndrome after vaccination administration, both of which occurred within eight months of tumor resection and were responsive to steroids. Autoimmune and infectious workup for other causes of nephrotic syndrome was negative. This is the first reported case of nephrotic syndrome associated with mediastinal teratoma.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paraneoplastic Syndromes / Teratoma / Mediastinal Neoplasms / Nephrotic Syndrome Type of study: Diagnostic_studies / Prognostic_studies Limits: Child / Female / Humans Language: En Journal: J Pediatr Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2023 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paraneoplastic Syndromes / Teratoma / Mediastinal Neoplasms / Nephrotic Syndrome Type of study: Diagnostic_studies / Prognostic_studies Limits: Child / Female / Humans Language: En Journal: J Pediatr Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2023 Document type: Article Country of publication: