Foreign Body Granuloma Originating From the Lateral Process of Malleus: A Case Series of 19 Children.
Otol Neurotol
; 44(7): 702-708, 2023 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-37311639
ABSTRACT
OBJECTIVE:
A special presentation of foreign body granuloma originating from the lateral process of the malleus (FBGLP) was noted in the absence of a history of foreign body entry into the external auditory canal (EAC). This study reported the clinical features, pathology, and prognosis of patients with FBGLP.DESIGN:
Retrospective study.SETTING:
Shandong Provincial ENT Hospital. PATIENTS Nineteen pediatric patients (age, 1-10 yr) with FBGLP.INTERVENTIONS:
Clinical data were collected from January 2018 to January 2022. MAIN OUTCOMEMEASURES:
Clinicopathologic characteristics of the patients were analyzed.RESULTS:
All patients had an acute course, and were within 3 months of ineffective medical treatment. The most common symptoms were suppurative (57.9%) and hemorrhagic (42.1%) otorrhea. FBGLP imaging examinations demonstrated a soft mass blocking the EAC without bone destruction and occasionally concomitant effusion in the middle ear. The most common pathologic findings were foreign body granuloma (94.7%,18/19), granulation tissue (73.7%, 14/19), keratotic precipitate (73.7%, 14/19), calcium deposition (63.2%, 12/19), hair shafts (47.4%, 9/19), cholesterol crystals (5, 26.3%), and hemosiderin (15.8%, 3/19). Foreign body granuloma and granulation tissue showed higher expression levels of CD68 and cleaved caspase-3 than did the normal tympanic mucosa, whereas Ki-67 levels were similarly low in all tissues. The patients were followed up for 3 months to 4 years without recurrence.CONCLUSION:
FBGLP is caused by endogenous foreign particles in the ear. We recommend the trans-external auditory meatus approach for FBGLP surgical excision, as this shows promising outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Granuloma, Foreign-Body
/
Malleus
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Language:
En
Journal:
Otol Neurotol
Journal subject:
NEUROLOGIA
/
OTORRINOLARINGOLOGIA
Year:
2023
Document type:
Article