Social and early life determinants of survival from cradle to grave: A case study in wild baboons.
Neurosci Biobehav Rev
; 152: 105282, 2023 09.
Article
in En
| MEDLINE
| ID: mdl-37321362
ABSTRACT
Field studies of natural mammal populations present powerful opportunities to investigate the determinants of health and aging using fine-grained observations of known individuals across the life course. Here, we synthesize five decades of findings from one such study the wild baboons of the Amboseli ecosystem in Kenya. First, we discuss the profound associations between early life adversity, adult social conditions, and key aging outcomes in this population, especially survival. Second, we review potential mediators of the relationship between early life adversity and survival in our population. Notably, our tests of two leading candidate mediators-social isolation and glucocorticoid levels-fail to identify a single, strong mediator of early life effects on adult survival. Instead, early adversity, social isolation, and glucocorticoids are independently linked to adult lifespans, suggesting considerable scope for mitigating the negative consequences of early life adversity. Third, we review our work on the evolutionary rationale for early life effects on mortality, which currently argues against clear predictive adaptive responses. Finally, we end by highlighting major themes emerging from the study of sociality, development, and aging in the Amboseli baboons, as well as important open questions for future work.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Social Behavior
/
Ecosystem
Type of study:
Prognostic_studies
Aspects:
Determinantes_sociais_saude
/
Equity_inequality
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurosci Biobehav Rev
Year:
2023
Document type:
Article
Affiliation country: