Disturbed Matrix Metalloproteinases Activity in Age-Related Macular Degeneration.
Adv Exp Med Biol
; 1415: 21-26, 2023.
Article
in En
| MEDLINE
| ID: mdl-37440009
ABSTRACT
Matrix metalloproteinases (MMPs) are a tightly regulated family of proteolytic enzymes that break down extracellular matrix (ECM) and basement membrane components. Because it is associated with development, morphogenesis, tissue remodeling, and repair, ECM remodeling is an important mechanism. MMPs are thought to act as a double-edged sword, as they contribute to maintaining photoreceptors/retinal pigment epithelium (RPE)/Bruch's membrane (BM)/choroid complex homeostasis and also contribute to the onset and progression of age-related macular degeneration (AMD). Polymorphisms and/or altered expression in MMPs and their tissue inhibitors (TIMPs) are associated with age-related macular degeneration (AMD). Here, we review the evidence for MMPs' role in the onset and progression of AMD via addressing their regulation and TIMPs' significant regulatory functions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Macular Degeneration
Limits:
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
2023
Document type:
Article
Affiliation country: