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Associations between area-level arsenic exposure and adverse birth outcomes: An Echo-wide cohort analysis.
Lewis, Jonathan V; Knapp, Emily A; Bakre, Shivani; Dickerson, Aisha S; Bastain, Theresa M; Bendixsen, Casper; Bennett, Deborah H; Camargo, Carlos A; Cassidy-Bushrow, Andrea E; Colicino, Elena; D'Sa, Viren; Dabelea, Dana; Deoni, Sean; Dunlop, Anne L; Elliott, Amy J; Farzan, Shohreh F; Ferrara, Assiamira; Fry, Rebecca C; Hartert, Tina; Howe, Caitlin G; Kahn, Linda G; Karagas, Margaret R; Ma, Teng-Fei; Koinis-Mitchell, Daphne; MacKenzie, Debra; Maldonado, Luis E; Merced-Nieves, Francheska M; Neiderhiser, Jenae M; Nigra, Anne E; Niu, Zhongzheng; Nozadi, Sara S; Rivera-Núñez, Zorimar; O'Connor, Thomas G; Osmundson, Sarah; Padula, Amy M; Peterson, Alicia K; Sherris, Allison R; Starling, Anne; Straughen, Jennifer K; Wright, Rosalind J; Zhao, Qi; Kress, Amii M.
Affiliation
  • Lewis JV; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  • Knapp EA; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  • Bakre S; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  • Dickerson AS; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  • Bastain TM; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
  • Bendixsen C; Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA.
  • Bennett DH; Department of Public Health Sciences, University of California Davis, Davis, CA, USA.
  • Camargo CA; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Cassidy-Bushrow AE; Department of Public Health Sciences, Henry Ford Health, Detroit, MI, USA.
  • Colicino E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • D'Sa V; Department of Pediatrics, Rhode Island Hospital, Providence, RI, USA.
  • Dabelea D; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
  • Deoni S; Bill and Melinda Gates Foundation, Seattle, WA, USA.
  • Dunlop AL; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Elliott AJ; Avera Research Institute, Sioux Falls, SD, USA; Department of Pediatrics, University of South Dakota School of Medicine, Vermillion, SD, USA.
  • Farzan SF; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
  • Ferrara A; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
  • Fry RC; Department of Environmental Sciences and Engineering, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
  • Hartert T; Departments of Medicine and Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Howe CG; Dartmouth College Geisel School of Medicine, Hanover, NH, USA.
  • Kahn LG; Departments of Pediatrics and Population Health, NYU Grossman School of Medicine, New York, NY, USA.
  • Karagas MR; Dartmouth College Geisel School of Medicine, Hanover, NH, USA.
  • Ma TF; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
  • Koinis-Mitchell D; Department of Pediatrics, Rhode Island Hospital, Providence, RI, USA.
  • MacKenzie D; Community Environmental Health Program, University of New Mexico College of Pharmacy, Health Sciences Center, Albuquerque, NM, USA.
  • Maldonado LE; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
  • Merced-Nieves FM; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Neiderhiser JM; Department of Psychology, Penn State University, University Park, PA, USA.
  • Nigra AE; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
  • Niu Z; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
  • Nozadi SS; Community Environmental Health Program, College of Pharmacy, Health Sciences Center, Albuquerque, NM, USA.
  • Rivera-Núñez Z; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, New Brunswick, NJ, USA.
  • O'Connor TG; Departments of Psychiatry, Neuroscience, Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA.
  • Osmundson S; Department of OB/GYN, Vanderbilt University School of Medicine, Nashville, TN, USA.
  • Padula AM; Department of Gynecology, Obstetrics and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, CA, USA.
  • Peterson AK; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
  • Sherris AR; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
  • Starling A; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
  • Straughen JK; Department of Public Health Sciences, Henry Ford Health, Detroit, MI, USA.
  • Wright RJ; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Zhao Q; Department of Preventive Medicine, University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA.
  • Kress AM; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: akress1@jhu.edu.
Environ Res ; 236(Pt 2): 116772, 2023 11 01.
Article in En | MEDLINE | ID: mdl-37517496
ABSTRACT

BACKGROUND:

Drinking water is a common source of exposure to inorganic arsenic. In the US, the Safe Drinking Water Act (SDWA) was enacted to protect consumers from exposure to contaminants, including arsenic, in public water systems (PWS). The reproductive effects of preconception and prenatal arsenic exposure in regions with low to moderate arsenic concentrations are not well understood.

OBJECTIVES:

This study examined associations between preconception and prenatal exposure to arsenic violations in water, measured via residence in a county with an arsenic violation in a regulated PWS during pregnancy, and five birth

outcomes:

birth weight, gestational age at birth, preterm birth, small for gestational age (SGA), and large for gestational age (LGA).

METHODS:

Data for arsenic violations in PWS, defined as concentrations exceeding 10 parts per billion, were obtained from the Safe Drinking Water Information System. Participants of the Environmental influences on Child Health Outcomes Cohort Study were matched to arsenic violations by time and location based on residential history data. Multivariable, mixed effects regression models were used to assess the relationship between preconception and prenatal exposure to arsenic violations in drinking water and birth outcomes.

RESULTS:

Compared to unexposed infants, continuous exposure to arsenic from three months prior to conception through birth was associated with 88.8 g higher mean birth weight (95% CI 8.2, 169.5), after adjusting for individual-level confounders. No statistically significant associations were observed between any preconception or prenatal violations exposure and gestational age at birth, preterm birth, SGA, or LGA.

CONCLUSIONS:

Our study did not identify associations between preconception and prenatal arsenic exposure, defined by drinking water exceedances, and adverse birth outcomes. Exposure to arsenic violations in drinking water was associated with higher birth weight. Future studies would benefit from more precise geodata of water system service areas, direct household drinking water measurements, and exposure biomarkers.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arsenic / Prenatal Exposure Delayed Effects / Drinking Water / Premature Birth Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Child / Female / Humans / Infant / Newborn / Pregnancy Language: En Journal: Environ Res Year: 2023 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arsenic / Prenatal Exposure Delayed Effects / Drinking Water / Premature Birth Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Child / Female / Humans / Infant / Newborn / Pregnancy Language: En Journal: Environ Res Year: 2023 Document type: Article Affiliation country: