Exercise and diet reduce muscle insulin resistance in obese Zucker rat.
Am J Physiol
; 251(3 Pt 1): E299-305, 1986 Sep.
Article
in En
| MEDLINE
| ID: mdl-3752241
ABSTRACT
Two treatments that increase skeletal muscle insulin action are exercise training and high-carbohydrate diet. The purpose of the present study was to determine whether exercise training and a diet high in carbohydrates could function synergistically to reduce the muscle insulin resistance in the obese Zucker rat. Obese rats 4 wk of age were randomly assigned to an exercise or sedentary group. Each group was subdivided by diet with one-half of the rats fed a high-carbohydrate diet and one-half fed a high-fat diet. Lean Zucker rats fed the high-fat diet were used as controls. Muscle insulin resistance was assessed during hindlimb perfusion with a submaximally stimulating concentration of insulin. Exercise training and the high-carbohydrate diet increased the rate of muscle glucose uptake in the obese rat by 46 and 53%, respectively. More importantly, the combined effect of exercise training and high-carbohydrate diet was greater than the sum of their individual effects. Glycogen synthesis paralleled glucose uptake and was the major pathway for intracellular glucose disposal. Muscle glucose uptake for exercise-trained, high-carbohydrate fed obese rats was comparable with that of lean controls. It is concluded that exercise training and the high-carbohydrate diet functioned synergistically to reduce the muscle insulin resistance in the obese rat.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Physical Conditioning, Animal
/
Insulin Resistance
/
Dietary Carbohydrates
/
Muscles
/
Obesity
Limits:
Animals
Language:
En
Journal:
Am J Physiol
Year:
1986
Document type:
Article