Your browser doesn't support javascript.
loading
Apolipoprotein E-associated Lipoprotein Glomerulo-tubulopathy.
Tanimizu, Hikaru; Hara, Risa; Sekine, Akinari; Inoue, Noriko; Hasegawa, Eiko; Tanaka, Kiho; Kono, Kei; Kinowaki, Keiichi; Ohashi, Kenichi; Okubo, Minoru; Yamaguchi, Yutaka; Kang, Dedong; Honda, Kazuho; Saito, Takao; Sawa, Naoki; Ubara, Yoshifumi; Hoshino, Junichi.
Affiliation
  • Tanimizu H; Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
  • Hara R; Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
  • Sekine A; Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
  • Inoue N; Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
  • Hasegawa E; Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
  • Tanaka K; Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
  • Kono K; Department of Pathology, Toranomon Hospital Toranomon, Japan.
  • Kinowaki K; Department of Pathology, Toranomon Hospital Toranomon, Japan.
  • Ohashi K; Department of Pathology, Toranomon Hospital Toranomon, Japan.
  • Okubo M; Department of Human Pathology, Tokyo Medical Dental University, Japan.
  • Yamaguchi Y; Section of Lipid Research and Department of Endocrinology and Metabolism, Toranomon Hospital, Japan.
  • Kang D; Yamaguchi's Pathology Laboratory, Japan.
  • Honda K; Department of Anatomy, Showa University School of Medicine, Japan.
  • Saito T; Department of Anatomy, Showa University School of Medicine, Japan.
  • Sawa N; Sanko Clinic, Japan.
  • Ubara Y; Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
  • Hoshino J; Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan.
Intern Med ; 62(15): 2209-2214, 2023.
Article in En | MEDLINE | ID: mdl-37532513
ABSTRACT
A 32-year-old man was admitted for the evaluation of proteinuria (5.69 g/day). A light microscopic examination showed markedly dilated glomerular capillary loops with vacuolated areas in many glomeruli, and vacuolated areas were seen on peritubular capillaries in the tubulointerstitium. When electron microscopy specimens prepared by pre-fixation with glutaraldehyde and post-fixation with osmium tetroxide were used for oil red staining, the deposition was confirmed on the affected areas. A genetic analysis of apoE showed that the lipoprotein glomerulopathy was due to apoE-Sendai (Arg145Pro, p.R163P) heterozygosity, which was found in not only the patient but also his mother and twin brother.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Kidney Diseases Type of study: Risk_factors_studies Limits: Adult / Humans / Male Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2023 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Kidney Diseases Type of study: Risk_factors_studies Limits: Adult / Humans / Male Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2023 Document type: Article Affiliation country: