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Children with a history of both maternal immune activation and prematurity are not at increased risk of ADHD symptoms.
Ellul, Pierre; Wallez, Solène; Acquaviva, Eric; Rosenzwajg, Michelle; Klatzmann, David; Delorme, Richard; Melchior, Maria.
Affiliation
  • Ellul P; Child and Adolescent Psychiatry Department, Robert Debré Hospital, University of Paris Cité, Paris, France.
  • Wallez S; Immunology, Immunopathology, Immunotherapy, INSERM U959, Pitié Salpétrière Hospital, Sorbonne University, Paris, France.
  • Acquaviva E; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, ERES, 75012, Paris, France.
  • Rosenzwajg M; Child and Adolescent Psychiatry Department, Robert Debré Hospital, University of Paris Cité, Paris, France.
  • Klatzmann D; Immunology, Immunopathology, Immunotherapy, INSERM U959, Pitié Salpétrière Hospital, Sorbonne University, Paris, France.
  • Delorme R; Immunology, Immunopathology, Immunotherapy, INSERM U959, Pitié Salpétrière Hospital, Sorbonne University, Paris, France.
  • Melchior M; Child and Adolescent Psychiatry Department, Robert Debré Hospital, University of Paris Cité, Paris, France.
Eur Child Adolesc Psychiatry ; 2023 Aug 03.
Article in En | MEDLINE | ID: mdl-37535256
ABSTRACT
Maternal autoimmune diseases (AID) are risk factors for Attention Deficit Hyperactivity Disorder (ADHD). Animal studies suggest that maternal immune activation (MIA) is a disease primer for ADHD, with second environmental factor precipitating the onset of the disease. Prematurity is also a major risk factor for ADHD. In this study, we sought to explore the interaction between parental AID and prematurity on ADHD risk in a community sample. Children of AID parents born prematurely appeared at increased odds of ADHD but these two risk factors do not appear to be additive (OR 1.39 [95 CI 0.75; 2.46]). Longitudinal studies with larger numbers of participants are needed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Eur Child Adolesc Psychiatry Journal subject: PEDIATRIA / PSIQUIATRIA Year: 2023 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Eur Child Adolesc Psychiatry Journal subject: PEDIATRIA / PSIQUIATRIA Year: 2023 Document type: Article Affiliation country: