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Therapeutic and Adverse Effect of Anti-PD1 Immunotherapy in Melanoma: A Retrospective, Single-Institute Study of 222 Patients.
Eikenes, Grethe; Liszkay, Gabriella; Balatoni, Tímea; Czirbesz, Kata; Hunyadi, Karen; Kozéki, Zsófia; Kispál, Mihály Tamás; Baranyai, Fanni; Danyi, Tímea; Bocs, Katalin; Kenessey, István.
Affiliation
  • Eikenes G; Department of Dermato-Oncology, National Institute of Oncology, H1122 Budapest, Hungary.
  • Liszkay G; Department of Dermato-Oncology, National Institute of Oncology, H1122 Budapest, Hungary.
  • Balatoni T; National Tumor Laboratory Project, H1122 Budapest, Hungary.
  • Czirbesz K; Department of Dermato-Oncology, National Institute of Oncology, H1122 Budapest, Hungary.
  • Hunyadi K; Department of Dermato-Oncology, National Institute of Oncology, H1122 Budapest, Hungary.
  • Kozéki Z; National Tumor Laboratory Project, H1122 Budapest, Hungary.
  • Kispál MT; Department of Dermato-Oncology, National Institute of Oncology, H1122 Budapest, Hungary.
  • Baranyai F; Department of Dermato-Oncology, National Institute of Oncology, H1122 Budapest, Hungary.
  • Danyi T; Department of Dermato-Oncology, National Institute of Oncology, H1122 Budapest, Hungary.
  • Bocs K; National Tumor Laboratory Project, H1122 Budapest, Hungary.
  • Kenessey I; Department of Dermato-Oncology, National Institute of Oncology, H1122 Budapest, Hungary.
Cancers (Basel) ; 15(15)2023 Aug 04.
Article in En | MEDLINE | ID: mdl-37568785
BACKGROUND: The introduction of immuno- and targeted therapeutic modalities meant a breakthrough step in the therapy of melanoma. As a checkpoint inhibitor, the more effective and less toxic anti-PD1 therapy followed an anti-CTLA4 approach. METHODS: From our patient pool, 222 advanced melanoma cases were selected, where anti-PD1 (pembrolizumab, nivolumab) therapy was initiated between March 2015 and December 2020. During our retrospective analysis, the efficacy and safety of the therapy were assessed. RESULTS: The median follow-up was 16 months (interval: 0-64 months), and 150 patients (67.6%) received therapy in the first line, while second and third line therapy was performed among 72 patients (32.4%) for the median of 7.0 months (0-60). In 50 cases, BRAF mutations were detected. Ninety-six patients showed objective response (11.3% CR, 32.0% PR). The median PFS was 10.0 months (0-60), and the median OS was 23.0 months (0-64). Autoimmune side effects were found in 79 patients (35.5%); grade 3 occurred in 6.3% of the cases, while 1 patient died due to fulminant pneumonitis (0.25%). CONCLUSION: Although the range of immunotherapeutic options is getting wider, in the management of melanoma patients, anti-PD1 monotherapy remains an important, effective, and safe method. However, significant correlation was found between the immune-related side effects and therapeutic efficacy.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancers (Basel) Year: 2023 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancers (Basel) Year: 2023 Document type: Article Affiliation country: Country of publication: