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Pathogenesis and Transmission Assessment of 3 Swine-Origin Influenza A(H3N2) Viruses With Zoonotic Risk to Humans Isolated in the United States, 2017-2020.
Sun, Xiangjie; Belser, Jessica A; Pulit-Penaloza, Joanna A; Brock, Nicole; Pappas, Claudia; Zanders, Natosha; Jang, Yunho; Jones, Joyce; Tumpey, Terrence M; Davis, C Todd; Maines, Taronna R.
Affiliation
  • Sun X; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Belser JA; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Pulit-Penaloza JA; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Brock N; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Pappas C; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Zanders N; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Jang Y; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Jones J; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Tumpey TM; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Davis CT; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Maines TR; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
J Infect Dis ; 229(4): 1107-1111, 2024 Apr 12.
Article in En | MEDLINE | ID: mdl-37602528
ABSTRACT
The sporadic occurrence of human infections with swine-origin influenza A(H3N2) viruses and the continual emergence of novel A(H3N2) viruses in swine herds underscore the necessity for ongoing assessment of the pandemic risk posed by these viruses. Here, we selected 3 recent novel swine-origin A(H3N2) viruses isolated between 2017 to 2020, bearing hemagglutinins from the 1990.1, 2010.1, or 2010.2 clades, and evaluated their ability to cause disease and transmit in a ferret model. We conclude that despite considerable genetic variances, all 3 contemporary swine-origin A(H3N2) viruses displayed a capacity for robust replication in the ferret respiratory tract and were also capable of limited airborne transmission. These findings highlight the continued public health risk of swine-origin A(H3N2) strains, especially in human populations with low cross-reactive immunity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza A virus / Swine Diseases / Orthomyxoviridae Infections / Influenza, Human Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Country/Region as subject: America do norte Language: En Journal: J Infect Dis Year: 2024 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza A virus / Swine Diseases / Orthomyxoviridae Infections / Influenza, Human Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Country/Region as subject: America do norte Language: En Journal: J Infect Dis Year: 2024 Document type: Article Affiliation country: