Dendrimer-conjugated isotretinoin for controlled transdermal drug delivery.
J Nanobiotechnology
; 21(1): 285, 2023 Aug 21.
Article
in En
| MEDLINE
| ID: mdl-37605256
ABSTRACT
BACKGROUND:
In the present study, we aimed to develop a novel isotretinoin delivery model for treating skin diseases, revealing its potential advantages in drug delivery and targeted therapy. Using a self-assembly strategy, we grafted a dendrimer, based on a well-defined branched structure for nanomedical devices, with a well-defined nanoarchitecture, yielding spherical, highly homogeneous molecules with multiple surface functionalities. Accordingly, a self-assembled dendrimer-conjugated system was developed to achieve the transdermal delivery of isotretinoin (13cRA-D).RESULTS:
Herein, 13cRA-D showed remarkable controlled release, characterized by slow release in normal tissues but accelerated release in tissues with low pH, such as sites of inflammation. These release characteristics could abrogate the nonteratogenic side effects of isotretinoin and allow efficient skin permeation. Moreover, 13cRA-D exhibited high therapeutic efficacy in acne models. Based on in vitro and in vivo experimental results, 13cRA-D afforded better skin penetration than isotretinoin and allowed lesion targeting. Additionally, 13cRA-D induced minimal skin irritation.CONCLUSION:
Our findings suggest that 13cRA-D is a safe and effective isotretinoin formulation for treating patients with skin disorders.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acne Vulgaris
/
Dendrimers
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Nanobiotechnology
Year:
2023
Document type:
Article
Affiliation country: