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Gallium reactivates first and second generation quinolone antibiotics towards drug-resistant Klebsiella pneumoniae.
Sultana, Tania; Duffin, Rebekah N; Blair, Victoria L; Andrews, Philip C.
Affiliation
  • Sultana T; School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. phil.andrews@monash.edu.
  • Duffin RN; School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. phil.andrews@monash.edu.
  • Blair VL; School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. phil.andrews@monash.edu.
  • Andrews PC; School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. phil.andrews@monash.edu.
Chem Commun (Camb) ; 59(74): 11093-11096, 2023 Sep 14.
Article in En | MEDLINE | ID: mdl-37642496
Herein, we report on a series of homoleptic [GaL3] and heteroleptic organometallic [GaMe2L] complexes of inactive quinolone antibiotics; nalidixic acid, oxolinic acid and norfloxacin with their antibacterial activity (MIC 0.024-0.781 µM) towards four multi-drug resistant strains of Klebsiella pneumoniae through complexation to gallium.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gallium / Klebsiella pneumoniae Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gallium / Klebsiella pneumoniae Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: Country of publication: